======= PIK3R4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R4
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30849|30849]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99570|Q99570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleus-vacuole junction|
|phosphatidylinositol 3-kinase complex, class III, type I|
|phosphatidylinositol 3-kinase complex, class III, type II|
|autophagy of peroxisome|
|phosphatidylinositol 3-kinase complex, class III|
|toll-like receptor 9 signaling pathway|
|late endosome to vacuole transport|
|receptor catabolic process|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|protein targeting to vacuole|
|cellular response to glucose starvation|
|establishment of protein localization to vacuole|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|protein localization to vacuole|
|regulation of lipid kinase activity|
|autophagosome|
|phagocytic vesicle membrane|
|regulation of phospholipid metabolic process|
|regulation of cytokinesis|
|toll-like receptor signaling pathway|
|axoneme|
|receptor metabolic process|
|phosphatidylinositol biosynthetic process|
|late endosome|
|pattern recognition receptor signaling pathway|
|positive regulation of lipid metabolic process|
|vacuolar transport|
|cellular response to starvation|
|microtubule cytoskeleton|
|macroautophagy|
|regulation of cell division|
|phosphatidylinositol metabolic process|
|response to starvation|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|innate immune response-activating signal transduction|
|cellular response to nutrient levels|
|protein kinase activity|
|phospholipid biosynthetic process|
|activation of innate immune response|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|glycerophospholipid metabolic process|
|cellular response to external stimulus|
|positive regulation of innate immune response|
|protein targeting|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|establishment of protein localization to organelle|
|regulation of innate immune response|
|positive regulation of defense response|
|response to nutrient levels|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|organophosphate biosynthetic process|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of transferase activity|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|intracellular protein transport|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|lipid metabolic process|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.5|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.21|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.02|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.01|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.97|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.7|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.86|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.89|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.91|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srp14|SRP14]]|0.516|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.507|
|[[:human genes:c:chchd4|CHCHD4]]|0.472|
|[[:human genes:t:triap1|TRIAP1]]|0.47|
|[[:human genes:a:aars|AARS]]|0.462|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.462|
|[[:human genes:u:uap1|UAP1]]|0.461|
|[[:human genes:t:thg1l|THG1L]]|0.456|
|[[:human genes:s:sec61g|SEC61G]]|0.454|
|[[:human genes:r:rtcb|RTCB]]|0.454|
|[[:human genes:a:apaf1|APAF1]]|0.454|
|[[:human genes:k:kdsr|KDSR]]|0.453|
|[[:human genes:c:cbfb|CBFB]]|0.451|
|[[:human genes:r:rnmt|RNMT]]|0.45|
|[[:human genes:r:rbmx2|RBMX2]]|0.448|
|[[:human genes:h:hccs|HCCS]]|0.444|
|[[:human genes:g:gmppb|GMPPB]]|0.442|
|[[:human genes:n:nae1|NAE1]]|0.441|
|[[:human genes:d:dhrsx|DHRSX]]|0.44|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.437|
|[[:human genes:d:dolk|DOLK]]|0.435|
|[[:human genes:d:dpagt1|DPAGT1]]|0.434|
|[[:human genes:e:eif4e|EIF4E]]|0.434|
|[[:human genes:r:rptor|RPTOR]]|0.429|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.428|
|[[:human genes:p:ppa2|PPA2]]|0.428|
|[[:human genes:r:rad1|RAD1]]|0.428|
|[[:human genes:d:ddx20|DDX20]]|0.428|
|[[:human genes:a:alg1|ALG1]]|0.426|
|[[:human genes:g:gemin6|GEMIN6]]|0.424|
|[[:human genes:n:nbn|NBN]]|0.423|
|[[:human genes:t:tti2|TTI2]]|0.423|
|[[:human genes:b:bap1|BAP1]]|0.421|
|[[:human genes:d:dohh|DOHH]]|0.419|
|[[:human genes:a:atxn10|ATXN10]]|0.417|
|[[:human genes:u:uhrf1|UHRF1]]|0.417|
|[[:human genes:t:timm22|TIMM22]]|0.416|
|[[:human genes:g:gfpt1|GFPT1]]|0.416|
|[[:human genes:l:lsm10|LSM10]]|0.414|
|[[:human genes:s:snapc5|SNAPC5]]|0.414|
|[[:human genes:m:mtor|MTOR]]|0.413|
|[[:human genes:v:vrk1|VRK1]]|0.412|
|[[:human genes:c:cept1|CEPT1]]|0.412|
|[[:human genes:p:pmm2|PMM2]]|0.412|
|[[:human genes:e:elp2|ELP2]]|0.41|
|[[:human genes:c:cnot4|CNOT4]]|0.405|
|[[:human genes:f:faf2|FAF2]]|0.405|
|[[:human genes:a:alg13|ALG13]]|0.402|
|[[:human genes:t:tprkb|TPRKB]]|0.402|
|[[:human genes:p:pelo|PELO]]|0.402|
|[[:human genes:h:hars|HARS]]|0.402|
|[[:human genes:a:atp2a2|ATP2A2]]|0.401|
|[[:human genes:c:casp9|CASP9]]|0.401|
|[[:human genes:e:eno1|ENO1]]|0.4|
|[[:human genes:g:gemin7|GEMIN7]]|0.4|
|[[:human genes:c:cct7|CCT7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 16/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5336
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R4 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>