======= PIK3R6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3R6
  * **<color #00a2e8>Official Name</color>**: phosphoinositide-3-kinase regulatory subunit 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=146850|146850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5UE93|Q5UE93]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3R6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3R6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611462|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:21393242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3K 1B p101|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase complex, class IB|
|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol 3-kinase complex|
|phosphatidylinositol 3-kinase signaling|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|lipid phosphorylation|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of T cell differentiation|
|regulation of phospholipid metabolic process|
|positive regulation of lymphocyte differentiation|
|regulation of cell killing|
|phosphatidylinositol biosynthetic process|
|regulation of T cell differentiation|
|platelet activation|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte mediated immunity|
|positive regulation of angiogenesis|
|phosphatidylinositol metabolic process|
|regulation of lymphocyte differentiation|
|positive regulation of vasculature development|
|positive regulation of hemopoiesis|
|positive regulation of T cell activation|
|lipid modification|
|regulation of leukocyte mediated immunity|
|glycerophospholipid biosynthetic process|
|positive regulation of leukocyte cell-cell adhesion|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|regulation of leukocyte differentiation|
|regulation of angiogenesis|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|glycerophospholipid metabolic process|
|angiogenesis|
|regulation of T cell activation|
|regulation of vasculature development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|positive regulation of lymphocyte activation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|wound healing|
|blood vessel development|
|regulation of body fluid levels|
|vasculature development|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|lipid metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13456
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3R6 Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>