======= PIM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIM1
  * **<color #00a2e8>Official Name</color>**: Pim-1 proto-oncogene, serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5292|5292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11309|P11309]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164960|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post- translational levels. Phosphorylation of CDKN1B,induces 14-3-3- proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. {ECO:0000269|PubMed:10664448, ECO:0000269|PubMed:12431783, ECO:0000269|PubMed:15528381, ECO:0000269|PubMed:16356754, ECO:0000269|PubMed:1825810, ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:19749799}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Kdo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cardioblast proliferation|
|vitamin D receptor signaling pathway|
|positive regulation of cell proliferation involved in heart morphogenesis|
|regulation of hematopoietic stem cell proliferation|
|regulation of cardioblast proliferation|
|cellular response to vitamin D|
|regulation of cell proliferation involved in heart morphogenesis|
|ribosomal small subunit binding|
|cellular response to vitamin|
|positive regulation of cardiac muscle cell proliferation|
|response to vitamin D|
|hyaluronan metabolic process|
|positive regulation of cardiac muscle tissue growth|
|regulation of animal organ formation|
|positive regulation of heart growth|
|regulation of heart morphogenesis|
|regulation of cardiac muscle cell proliferation|
|positive regulation of cardiac muscle tissue development|
|positive regulation of organ growth|
|regulation of cardiac muscle tissue growth|
|manganese ion binding|
|regulation of heart growth|
|regulation of stem cell proliferation|
|cellular response to nutrient|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|regulation of cardiac muscle tissue development|
|positive regulation of animal organ morphogenesis|
|response to vitamin|
|regulation of organ growth|
|mucopolysaccharide metabolic process|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|glycosaminoglycan metabolic process|
|negative regulation of DNA-binding transcription factor activity|
|intracellular receptor signaling pathway|
|aminoglycan metabolic process|
|positive regulation of developmental growth|
|protein stabilization|
|protein autophosphorylation|
|response to nutrient|
|cellular response to nutrient levels|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|regulation of protein stability|
|regulation of developmental growth|
|transcription factor binding|
|cellular response to external stimulus|
|protein serine/threonine kinase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of hemopoiesis|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|cell population proliferation|
|regulation of growth|
|cytokine-mediated signaling pathway|
|response to lipid|
|nucleolus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|protein phosphorylation|
|negative regulation of cell death|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|negative regulation of molecular function|
|phosphorylation|
|cell cycle|
|positive regulation of developmental process|
|ATP binding|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.7|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.81|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.465|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10470
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIM1 Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>