======= PIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIN1
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5300|5300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13526|Q13526]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354). {ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:16644721, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:22033920, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:23623683, ECO:0000269|PubMed:27561354}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|Rotamase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cis-trans isomerase activity|
|phosphothreonine residue binding|
|phosphoserine residue binding|
|positive regulation of cell growth involved in cardiac muscle cell development|
|negative regulation of amyloid-beta formation|
|mitogen-activated protein kinase kinase binding|
|negative regulation of amyloid precursor protein catabolic process|
|GTPase activating protein binding|
|postsynaptic cytosol|
|regulation of cell growth involved in cardiac muscle cell development|
|positive regulation of cardiac muscle cell differentiation|
|regulation of amyloid-beta formation|
|positive regulation of cardiocyte differentiation|
|positive regulation of cardiac muscle hypertrophy|
|positive regulation of muscle hypertrophy|
|positive regulation of ubiquitin-protein transferase activity|
|microtubule polymerization|
|positive regulation of cardiac muscle tissue growth|
|regulation of amyloid precursor protein catabolic process|
|phosphoprotein binding|
|regulation of cardiac muscle cell differentiation|
|positive regulation of heart growth|
|positive regulation of cardiac muscle tissue development|
|positive regulation of protein dephosphorylation|
|tau protein binding|
|motor activity|
|negative regulation of type I interferon production|
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|positive regulation of organ growth|
|microtubule polymerization or depolymerization|
|regulation of cardiocyte differentiation|
|regulation of ubiquitin-protein transferase activity|
|positive regulation of neuron apoptotic process|
|regulation of cardiac muscle hypertrophy|
|positive regulation of dephosphorylation|
|positive regulation of striated muscle cell differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|peptidyl-proline modification|
|regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of heart growth|
|negative regulation of ERK1 and ERK2 cascade|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of cardiac muscle tissue development|
|beta-catenin binding|
|regulation of muscle adaptation|
|positive regulation of muscle cell differentiation|
|protein polymerization|
|regulation of cytokinesis|
|positive regulation of neuron death|
|positive regulation of protein binding|
|regulation of organ growth|
|regulation of striated muscle cell differentiation|
|negative regulation of protein binding|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|regulation of type I interferon production|
|regulation of striated muscle tissue development|
|negative regulation of protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of protein dephosphorylation|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of neuron apoptotic process|
|negative regulation of cellular amide metabolic process|
|negative regulation of cellular response to growth factor stimulus|
|regulation of muscle cell differentiation|
|midbody|
|positive regulation of cell growth|
|negative regulation of MAPK cascade|
|regulation of cell division|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|positive regulation of developmental growth|
|positive regulation of Wnt signaling pathway|
|protein stabilization|
|positive regulation of binding|
|regulation of signal transduction by p53 class mediator|
|regulation of nuclear division|
|regulation of protein ubiquitination|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of dephosphorylation|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of muscle system process|
|positive regulation of growth|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|regulation of canonical Wnt signaling pathway|
|regulation of protein stability|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of neuron death|
|neuron projection|
|negative regulation of locomotion|
|regulation of developmental growth|
|response to hypoxia|
|glutamatergic synapse|
|response to decreased oxygen levels|
|regulation of Wnt signaling pathway|
|regulation of binding|
|response to oxygen levels|
|regulation of protein catabolic process|
|nuclear speck|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|regulation of cell growth|
|negative regulation of phosphorylation|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|regulation of cellular protein localization|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of system process|
|negative regulation of protein modification process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|microtubule-based process|
|regulation of growth|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of catabolic process|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.73|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.81|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIN1 Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>