======= PISD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PISD
  * **<color #00a2e8>Official Name</color>**: phosphatidylserine decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23761|23761]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UG56|Q9UG56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PISD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PISD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. {ECO:0000255|HAMAP-Rule:MF_03208}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PS Dcarbxylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylserine decarboxylase activity|
|phosphatidylethanolamine biosynthetic process|
|protein autoprocessing|
|phosphatidylethanolamine metabolic process|
|integral component of mitochondrial inner membrane|
|protein processing|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|protein maturation|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|mitochondrion|
|proteolysis|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.7|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.76|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.01|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.38|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.696|
|[[:human genes:h:hspd1|HSPD1]]|0.495|
|[[:human genes:p:pam16|PAM16]]|0.477|
|[[:human genes:a:apaf1|APAF1]]|0.476|
|[[:human genes:r:rnmt|RNMT]]|0.472|
|[[:human genes:p:pmm2|PMM2]]|0.463|
|[[:human genes:m:meaf6|MEAF6]]|0.461|
|[[:human genes:t:timm13|TIMM13]]|0.459|
|[[:human genes:t:tamm41|TAMM41]]|0.457|
|[[:human genes:u:uap1|UAP1]]|0.446|
|[[:human genes:c:crls1|CRLS1]]|0.446|
|[[:human genes:c:csnk2b|CSNK2B]]|0.443|
|[[:human genes:d:ddost|DDOST]]|0.441|
|[[:human genes:r:romo1|ROMO1]]|0.44|
|[[:human genes:a:alg5|ALG5]]|0.439|
|[[:human genes:r:rpn1|RPN1]]|0.438|
|[[:human genes:h:hccs|HCCS]]|0.437|
|[[:human genes:t:triap1|TRIAP1]]|0.436|
|[[:human genes:g:gfpt1|GFPT1]]|0.435|
|[[:human genes:r:rptor|RPTOR]]|0.434|
|[[:human genes:a:aars|AARS]]|0.432|
|[[:human genes:g:gmppb|GMPPB]]|0.428|
|[[:human genes:m:mtor|MTOR]]|0.425|
|[[:human genes:b:bap1|BAP1]]|0.425|
|[[:human genes:p:plaa|PLAA]]|0.425|
|[[:human genes:e:eprs|EPRS]]|0.425|
|[[:human genes:t:taz|TAZ]]|0.42|
|[[:human genes:c:cep350|CEP350]]|0.416|
|[[:human genes:m:mars|MARS]]|0.413|
|[[:human genes:a:atp2a2|ATP2A2]]|0.413|
|[[:human genes:a:alg1|ALG1]]|0.413|
|[[:human genes:c:cycs|CYCS]]|0.411|
|[[:human genes:b:bak1|BAK1]]|0.41|
|[[:human genes:p:pmpcb|PMPCB]]|0.407|
|[[:human genes:n:nae1|NAE1]]|0.406|
|[[:human genes:s:sec61g|SEC61G]]|0.403|
|[[:human genes:s:srp72|SRP72]]|0.403|
|[[:human genes:p:pelo|PELO]]|0.401|
|[[:human genes:t:tsen54|TSEN54]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 501
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PISD Expression in NALM6 Cells: 5.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>