======= PITPNM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PITPNM1
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol transfer protein membrane associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9600|9600]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00562|O00562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PITPNM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PITPNM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608794|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. {ECO:0000250, ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:11909959, ECO:0000269|PubMed:15545272, ECO:0000269|PubMed:15723057}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IP trans|
|LNS2|
|DDHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylcholine transporter activity|
|phosphatidylinositol transfer activity|
|phosphatidic acid binding|
|phosphatidylcholine binding|
|phototransduction|
|cleavage furrow|
|receptor tyrosine kinase binding|
|detection of light stimulus|
|cytoplasmic ribonucleoprotein granule|
|cell body|
|lipid droplet|
|phosphatidylinositol binding|
|phospholipid transport|
|Golgi cisterna membrane|
|phosphatidylinositol biosynthetic process|
|detection of external stimulus|
|organophosphate ester transport|
|detection of abiotic stimulus|
|microtubule organizing center|
|midbody|
|phosphatidylinositol metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|lipid transport|
|response to light stimulus|
|glycerophospholipid metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to radiation|
|organic anion transport|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|anion transport|
|detection of stimulus|
|calcium ion binding|
|brain development|
|head development|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|central nervous system development|
|response to abiotic stimulus|
|lipid metabolic process|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.72|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.7|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PITPNM1 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>