======= PITX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PITX1
  * **<color #00a2e8>Official Name</color>**: paired like homeodomain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5307|5307]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78337|P78337]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PITX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PITX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|OAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branchiomeric skeletal muscle development|
|myoblast fate commitment|
|embryonic hindlimb morphogenesis|
|myoblast differentiation|
|hindlimb morphogenesis|
|pituitary gland development|
|RNA polymerase II transcription factor binding|
|diencephalon development|
|endocrine system development|
|skeletal muscle tissue development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|skeletal muscle organ development|
|limb morphogenesis|
|appendage morphogenesis|
|cartilage development|
|appendage development|
|limb development|
|transcription factor complex|
|connective tissue development|
|cell fate commitment|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|forebrain development|
|gland development|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|embryonic morphogenesis|
|DNA-binding transcription factor activity|
|brain development|
|head development|
|nucleolus|
|embryo development|
|central nervous system development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.469|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PITX1 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>