======= PJA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PJA2
  * **<color #00a2e8>Official Name</color>**: praja ring finger ubiquitin ligase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9867|9867]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43164|O43164]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PJA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PJA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619341|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes. {ECO:0000269|PubMed:12036302, ECO:0000269|PubMed:21423175}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-rbx1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of toll-like receptor 2 signaling pathway|
|regulation of toll-like receptor 2 signaling pathway|
|protein kinase A catalytic subunit binding|
|regulation of protein kinase A signaling|
|protein kinase A regulatory subunit binding|
|positive regulation of toll-like receptor signaling pathway|
|positive regulation of p38MAPK cascade|
|hippo signaling|
|long-term memory|
|regulation of p38MAPK cascade|
|intermediate filament cytoskeleton|
|regulation of macrophage activation|
|regulation of toll-like receptor signaling pathway|
|memory|
|positive regulation of JNK cascade|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|postsynaptic membrane|
|ubiquitin protein ligase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|ubiquitin-protein transferase activity|
|postsynaptic density|
|learning or memory|
|cognition|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of MAPK cascade|
|cell junction|
|behavior|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|Golgi membrane|
|regulation of cell activation|
|protein ubiquitination|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|positive regulation of immune response|
|endoplasmic reticulum membrane|
|defense response to other organism|
|protein modification by small protein conjugation or removal|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|nervous system process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.75|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PJA2 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>