======= PKDCC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKDCC
  * **<color #00a2e8>Official Name</color>**: protein kinase domain containing, cytoplasmic
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91461|91461]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q504Y2|Q504Y2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKDCC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKDCC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q5RJI4, ECO:0000269|PubMed:25171405}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Golgi to plasma membrane protein transport|
|regulation of Golgi to plasma membrane protein transport|
|positive regulation of chondrocyte differentiation|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|negative regulation of protein localization to membrane|
|positive regulation of cartilage development|
|embryonic digestive tract development|
|positive regulation of bone mineralization|
|lung alveolus development|
|non-membrane spanning protein tyrosine kinase activity|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|bone mineralization|
|regulation of chondrocyte differentiation|
|regulation of cartilage development|
|regulation of bone mineralization|
|multicellular organism growth|
|positive regulation of ossification|
|roof of mouth development|
|biomineralization|
|regulation of biomineralization|
|biomineral tissue development|
|regulation of biomineral tissue development|
|regulation of protein localization to plasma membrane|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|digestive tract development|
|digestive system development|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|limb morphogenesis|
|appendage morphogenesis|
|lung development|
|respiratory tube development|
|appendage development|
|limb development|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|regulation of ossification|
|respiratory system development|
|protein kinase activity|
|ossification|
|developmental growth|
|growth|
|embryonic organ development|
|negative regulation of transport|
|skeletal system development|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|tube development|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|Golgi apparatus|
|regulation of protein localization|
|phosphorylation|
|positive regulation of developmental process|
|ATP binding|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5143
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKDCC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>