======= PKDREJ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKDREJ
  * **<color #00a2e8>Official Name</color>**: polycystin family receptor for egg jelly
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10343|10343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NTG1|Q9NTG1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKDREJ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKDREJ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604670|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|REJ|
|PLAT|
|PKD channel|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acrosome reaction|
|detection of mechanical stimulus|
|calcium channel activity|
|detection of external stimulus|
|detection of abiotic stimulus|
|single fertilization|
|fertilization|
|calcium ion transmembrane transport|
|response to mechanical stimulus|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|calcium ion binding|
|cation transport|
|sexual reproduction|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|reproductive process|
|reproduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.74|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.86|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKDREJ Expression in NALM6 Cells: -0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>