======= PKN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKN1
  * **<color #00a2e8>Official Name</color>**: protein kinase N1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5585|5585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16512|Q16512]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser- 159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro. {ECO:0000269|PubMed:11104762, ECO:0000269|PubMed:12514133, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:8557118, ECO:0000269|PubMed:8621664, ECO:0000269|PubMed:9175763}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Pkinase C|
|HR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone kinase activity (H3-T11 specific)|
|histone H3-T11 phosphorylation|
|histone-threonine phosphorylation|
|B cell apoptotic process|
|regulation of germinal center formation|
|protein kinase C activity|
|negative regulation of B cell proliferation|
|lymphocyte apoptotic process|
|GTP-Rho binding|
|hyperosmotic response|
|leukocyte apoptotic process|
|B cell homeostasis|
|histone phosphorylation|
|negative regulation of B cell activation|
|spleen development|
|activation of JUN kinase activity|
|androgen receptor binding|
|protein kinase C binding|
|lymphocyte homeostasis|
|Rac GTPase binding|
|cleavage furrow|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|nuclear receptor transcription coactivator activity|
|leukocyte homeostasis|
|positive regulation of JUN kinase activity|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|response to osmotic stress|
|negative regulation of leukocyte proliferation|
|JNK cascade|
|peptidyl-threonine phosphorylation|
|epithelial cell migration|
|epithelium migration|
|regulation of JUN kinase activity|
|peptidyl-threonine modification|
|tissue migration|
|stress-activated MAPK cascade|
|renal system process|
|histone deacetylase binding|
|histone binding|
|positive regulation of JNK cascade|
|regulation of production of molecular mediator of immune response|
|stress-activated protein kinase signaling cascade|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|activation of MAPK activity|
|midbody|
|regulation of adaptive immune response|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|ameboidal-type cell migration|
|peptidyl-serine phosphorylation|
|negative regulation of leukocyte activation|
|regulation of JNK cascade|
|negative regulation of cell activation|
|peptidyl-serine modification|
|homeostasis of number of cells|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of protein kinase activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|negative regulation of kinase activity|
|positive regulation of MAP kinase activity|
|endosome|
|negative regulation of transferase activity|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|protein serine/threonine kinase activity|
|histone modification|
|MAPK cascade|
|covalent chromatin modification|
|signal transduction by protein phosphorylation|
|chromatin binding|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|chromatin organization|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of cell motility|
|apoptotic process|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|localization of cell|
|cell motility|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.49|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.18|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5539
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKN1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>