======= PKP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKP2
  * **<color #00a2e8>Official Name</color>**: plakophilin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5318|5318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99959|Q99959]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602861|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in junctional plaques. {ECO:0000269|PubMed:22781308}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|desmosome assembly|
|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|
|maintenance of animal organ identity|
|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|
|adherens junction maintenance|
|intermediate filament bundle assembly|
|cardiac muscle cell-cardiac muscle cell adhesion|
|desmosome organization|
|alpha-catenin binding|
|intermediate filament binding|
|messenger ribonucleoprotein complex|
|bundle of His cell to Purkinje myocyte communication|
|regulation of ventricular cardiac muscle cell action potential|
|cell junction maintenance|
|cell communication by electrical coupling involved in cardiac conduction|
|cell communication by electrical coupling|
|ventricular cardiac muscle cell action potential|
|intermediate filament organization|
|desmosome|
|cell-cell signaling involved in cardiac conduction|
|regulation of cardiac muscle cell action potential|
|positive regulation of sodium ion transport|
|sodium channel regulator activity|
|heterotypic cell-cell adhesion|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|cell communication involved in cardiac conduction|
|intercalated disc|
|cellular component maintenance|
|molecular adaptor activity|
|ventricular cardiac muscle tissue morphogenesis|
|cardiac muscle cell action potential|
|regulation of action potential|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|protein kinase C binding|
|ventricular cardiac muscle tissue development|
|homotypic cell-cell adhesion|
|adherens junction|
|cornified envelope|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|adherens junction organization|
|heart contraction|
|regulation of sodium ion transport|
|muscle organ morphogenesis|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|heart process|
|cell-cell adherens junction|
|cell-cell junction assembly|
|striated muscle contraction|
|actin filament-based movement|
|cornification|
|intermediate filament|
|ion channel binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|multicellular organismal signaling|
|cell-cell junction organization|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cell junction assembly|
|cardiac chamber development|
|cell-cell junction|
|protein localization to plasma membrane|
|cell junction organization|
|protein localization to cell periphery|
|keratinization|
|regulation of muscle system process|
|regulation of heart contraction|
|heart morphogenesis|
|muscle contraction|
|positive regulation of ion transport|
|keratinocyte differentiation|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|cadherin binding|
|epidermal cell differentiation|
|skin development|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|epidermis development|
|regulation of membrane potential|
|supramolecular fiber organization|
|muscle structure development|
|protein localization to membrane|
|cell-cell adhesion|
|heart development|
|cell junction|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|epithelial cell differentiation|
|regulation of ion transport|
|negative regulation of cell differentiation|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of transport|
|regulation of cellular component movement|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.84|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11047
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKP2 Expression in NALM6 Cells: 1.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>