======= PLAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLAT
  * **<color #00a2e8>Official Name</color>**: plasminogen activator, tissue type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5327|5327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00750|P00750]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn1|
|Kringle|
|Trypsin|
|EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-synaptic signaling by BDNF|
|trans-synaptic signaling by BDNF, modulating synaptic transmission|
|smooth muscle cell migration|
|plasminogen activation|
|trans-synaptic signaling, modulating synaptic transmission|
|fibrinolysis|
|muscle cell migration|
|platelet-derived growth factor receptor signaling pathway|
|phosphoprotein binding|
|zymogen activation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|negative regulation of wound healing|
|apical part of cell|
|regulation of blood coagulation|
|regulation of hemostasis|
|Schaffer collateral - CA1 synapse|
|regulation of coagulation|
|negative regulation of response to wounding|
|secretory granule|
|regulation of wound healing|
|protein processing|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|protein maturation|
|blood coagulation|
|coagulation|
|hemostasis|
|signaling receptor binding|
|response to hypoxia|
|glutamatergic synapse|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|response to oxygen levels|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|wound healing|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to wounding|
|cell surface|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|cell migration|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|locomotion|
|regulation of response to stress|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|extracellular region|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.03|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.78|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.7|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.83|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLAT Expression in NALM6 Cells: 2.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>