======= PLEKHH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHH2
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology, MyTH4 and FERM domain containing H2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130271|130271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IVE3|Q8IVE3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|MyTH4|
|FERM M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of actin filament organization|
|actin binding|
|nuclear body|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|negative regulation of cellular component organization|
|identical protein binding|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHH2 Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>