======= PLXNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLXNB1
  * **<color #00a2e8>Official Name</color>**: plexin B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5364|5364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43157|O43157]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLXNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLXNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIG|
|Plexin cytopl|
|PSI|
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|
|inhibitory synapse assembly|
|negative regulation of osteoblast proliferation|
|bone trabecula morphogenesis|
|semaphorin receptor complex|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|ossification involved in bone maturation|
|GTPase activating protein binding|
|bone maturation|
|animal organ maturation|
|regulation of osteoblast proliferation|
|semaphorin receptor binding|
|semaphorin-plexin signaling pathway|
|trabecula morphogenesis|
|positive regulation of axonogenesis|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|synapse assembly|
|regulation of phosphatidylinositol 3-kinase signaling|
|anatomical structure maturation|
|transmembrane signaling receptor activity|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of axonogenesis|
|bone development|
|signaling receptor activity|
|developmental maturation|
|axon guidance|
|neuron projection guidance|
|ossification|
|synapse organization|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|GTPase activator activity|
|regulation of cell morphogenesis involved in differentiation|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|positive regulation of GTPase activity|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.88|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.71|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.76|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5041
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLXNB1 Expression in NALM6 Cells: 4.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>