======= PLXNB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLXNB3
  * **<color #00a2e8>Official Name</color>**: plexin B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5365|5365]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULL4|Q9ULL4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLXNB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLXNB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300214|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIG|
|Sema|
|PSI|
|Plexin cytopl|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rho GDP-dissociation inhibitor binding|
|negative regulation of lamellipodium assembly|
|negative regulation of lamellipodium organization|
|semaphorin receptor complex|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|cell-cell adhesion mediator activity|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of lamellipodium assembly|
|semaphorin-plexin signaling pathway|
|regulation of lamellipodium organization|
|negative regulation of GTPase activity|
|positive chemotaxis|
|positive regulation of axonogenesis|
|positive regulation of endothelial cell proliferation|
|regulation of endothelial cell proliferation|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|cell chemotaxis|
|protein domain specific binding|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|negative regulation of cell migration|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|cell surface|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|negative regulation of catalytic activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.7|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.7|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc6a17|SLC6A17]]|0.446|
|[[:human genes:t:tyms|TYMS]]|0.427|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.425|
|[[:human genes:c:cdc6|CDC6]]|0.425|
|[[:human genes:t:ticrr|TICRR]]|0.42|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.42|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.417|
|[[:human genes:k:kctd17|KCTD17]]|0.416|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.413|
|[[:human genes:c:col2a1|COL2A1]]|0.413|
|[[:human genes:c:copg1|COPG1]]|0.411|
|[[:human genes:z:znf655|ZNF655]]|0.409|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.408|
|[[:human genes:d:dock6|DOCK6]]|0.403|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLXNB3 Expression in NALM6 Cells: -1.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>