======= PMVK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PMVK
  * **<color #00a2e8>Official Name</color>**: phosphomevalonate kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10654|10654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15126|Q15126]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PMVK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PMVK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607622|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P-mevalo kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphomevalonate kinase activity|
|isopentenyl diphosphate biosynthetic process, mevalonate pathway|
|isopentenyl diphosphate biosynthetic process|
|isopentenyl diphosphate metabolic process|
|response to cholesterol|
|isoprenoid biosynthetic process|
|acetyl-CoA metabolic process|
|response to sterol|
|cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|thioester metabolic process|
|acyl-CoA metabolic process|
|peroxisome|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|response to alcohol|
|phospholipid biosynthetic process|
|coenzyme metabolic process|
|steroid metabolic process|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|response to lipid|
|organophosphate metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|ATP binding|
|response to oxygen-containing compound|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.2|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.09|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.09|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.95|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.85|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.85|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.83|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.74|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.72|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.7|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.7|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.71|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.71|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.74|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.74|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.8|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.8|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.83|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.89|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.91|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.99|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.06|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.06|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.09|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.11|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.23|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.24|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.39|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.52|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.58|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.67|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppcdc|PPCDC]]|0.722|
|[[:human genes:d:dhrsx|DHRSX]]|0.636|
|[[:human genes:p:pgm3|PGM3]]|0.623|
|[[:human genes:d:dnlz|DNLZ]]|0.616|
|[[:human genes:t:trmt61a|TRMT61A]]|0.614|
|[[:human genes:m:mettl1|METTL1]]|0.57|
|[[:human genes:s:srd5a3|SRD5A3]]|0.539|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.538|
|[[:human genes:p:pars2|PARS2]]|0.535|
|[[:human genes:p:ptar1|PTAR1]]|0.53|
|[[:human genes:f:fh|FH]]|0.524|
|[[:human genes:p:ppa1|PPA1]]|0.523|
|[[:human genes:t:ten1|TEN1]]|0.517|
|[[:human genes:w:wrb|WRB]]|0.515|
|[[:human genes:w:wdr83|WDR83]]|0.511|
|[[:human genes:r:rpia|RPIA]]|0.507|
|[[:human genes:t:trmt6|TRMT6]]|0.506|
|[[:human genes:n:nars2|NARS2]]|0.5|
|[[:human genes:t:tube1|TUBE1]]|0.493|
|[[:human genes:y:yars2|YARS2]]|0.486|
|[[:human genes:e:elp6|ELP6]]|0.483|
|[[:human genes:s:selrc1|SELRC1]]|0.48|
|[[:human genes:l:lars2|LARS2]]|0.478|
|[[:human genes:r:rft1|RFT1]]|0.477|
|[[:human genes:g:gnpnat1|GNPNAT1]]|0.476|
|[[:human genes:e:ears2|EARS2]]|0.473|
|[[:human genes:c:c1d|C1D]]|0.473|
|[[:human genes:p:polg|POLG]]|0.473|
|[[:human genes:d:dap3|DAP3]]|0.472|
|[[:human genes:m:mrpl21|MRPL21]]|0.471|
|[[:human genes:t:tmem242|TMEM242]]|0.47|
|[[:human genes:l:lsm10|LSM10]]|0.469|
|[[:human genes:p:pgs1|PGS1]]|0.465|
|[[:human genes:c:c16orf80|C16orf80]]|0.465|
|[[:human genes:m:mrps5|MRPS5]]|0.463|
|[[:human genes:g:g6pd|G6PD]]|0.459|
|[[:human genes:g:gemin7|GEMIN7]]|0.458|
|[[:human genes:d:ddx39a|DDX39A]]|0.458|
|[[:human genes:f:fkbpl|FKBPL]]|0.456|
|[[:human genes:p:ppcs|PPCS]]|0.455|
|[[:human genes:t:tubd1|TUBD1]]|0.452|
|[[:human genes:m:mrps6|MRPS6]]|0.448|
|[[:human genes:a:alg8|ALG8]]|0.446|
|[[:human genes:c:c15orf41|C15orf41]]|0.445|
|[[:human genes:t:tars2|TARS2]]|0.445|
|[[:human genes:k:kti12|KTI12]]|0.443|
|[[:human genes:p:polg2|POLG2]]|0.44|
|[[:human genes:g:gemin6|GEMIN6]]|0.439|
|[[:human genes:g:gemin4|GEMIN4]]|0.435|
|[[:human genes:s:sco2|SCO2]]|0.434|
|[[:human genes:a:adat2|ADAT2]]|0.432|
|[[:human genes:m:msto1|MSTO1]]|0.432|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.427|
|[[:human genes:g:gatc|GATC]]|0.426|
|[[:human genes:a:adat3|ADAT3]]|0.425|
|[[:human genes:s:slc7a1|SLC7A1]]|0.425|
|[[:human genes:m:mre11a|MRE11A]]|0.423|
|[[:human genes:i:iba57|IBA57]]|0.423|
|[[:human genes:k:kdsr|KDSR]]|0.418|
|[[:human genes:u:ugp2|UGP2]]|0.417|
|[[:human genes:m:mrpl23|MRPL23]]|0.417|
|[[:human genes:a:atpaf2|ATPAF2]]|0.416|
|[[:human genes:r:rbfa|RBFA]]|0.414|
|[[:human genes:c:cxorf56|CXorf56]]|0.414|
|[[:human genes:a:alg6|ALG6]]|0.414|
|[[:human genes:t:tsen15|TSEN15]]|0.413|
|[[:human genes:f:fastkd5|FASTKD5]]|0.413|
|[[:human genes:u:urm1|URM1]]|0.412|
|[[:human genes:g:get4|GET4]]|0.411|
|[[:human genes:n:n6amt1|N6AMT1]]|0.41|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.409|
|[[:human genes:b:bcs1l|BCS1L]]|0.407|
|[[:human genes:k:klf16|KLF16]]|0.407|
|[[:human genes:e:elp3|ELP3]]|0.404|
|[[:human genes:m:mrps34|MRPS34]]|0.404|
|[[:human genes:m:mtg1|MTG1]]|0.403|
|[[:human genes:r:rars2|RARS2]]|0.402|
|[[:human genes:g:gemin8|GEMIN8]]|0.402|
|[[:human genes:d:dolk|DOLK]]|0.402|
|[[:human genes:t:tpk1|TPK1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 80/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|1/26|
|breast|5/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|1/20|
|lung|12/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|5/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PMVK Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>