======= PNO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNO1
  * **<color #00a2e8>Official Name</color>**: partner of NOB1 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56902|56902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRX1|Q9NRX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604). {ECO:0000269|PubMed:25851604}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KH 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.42|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.25|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.01|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.73|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.72|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.72|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.74|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.74|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.77|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.85|
|[[:results:exp453|B02 10μM R08 exp453]]|1.86|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.89|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.9|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.91|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.95|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.98|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.02|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.03|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|2.06|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.1|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.17|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.58|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.76|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.8|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.514|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.487|
|[[:human genes:u:utp3|UTP3]]|0.476|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.476|
|[[:human genes:c:chaf1a|CHAF1A]]|0.468|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.443|
|[[:human genes:i:ik|IK]]|0.438|
|[[:human genes:d:dock6|DOCK6]]|0.437|
|[[:human genes:a:aamp|AAMP]]|0.434|
|[[:human genes:c:cdh24|CDH24]]|0.427|
|[[:human genes:v:vps28|VPS28]]|0.426|
|[[:human genes:t:ticrr|TICRR]]|0.42|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.419|
|[[:human genes:p:pole|POLE]]|0.414|
|[[:human genes:c:cdca3|CDCA3]]|0.413|
|[[:human genes:d:ddx41|DDX41]]|0.411|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.411|
|[[:human genes:r:rrp7a|RRP7A]]|0.407|
|[[:human genes:v:vasn|VASN]]|0.405|
|[[:human genes:p:psmb2|PSMB2]]|0.403|
|[[:human genes:p:prpf19|PRPF19]]|0.403|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNO1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>