======= POGZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POGZ
  * **<color #00a2e8>Official Name</color>**: pogo transposable element derived with ZNF domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23126|23126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z3K3|Q7Z3K3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POGZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POGZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614787|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. {ECO:0000269|PubMed:20562864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DDE 1|
|HTH Tnp Tc5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinetochore assembly|
|mitotic sister chromatid cohesion|
|kinetochore organization|
|RNA polymerase II core promoter sequence-specific DNA binding|
|centromere complex assembly|
|histone methyltransferase complex|
|sister chromatid cohesion|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|protein-DNA complex assembly|
|nuclear chromosome segregation|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear division|
|organelle fission|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cell cycle|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.75|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.77|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.81|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.89|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.99|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.04|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.07|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4126
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POGZ Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>