======= POLG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLG2
  * **<color #00a2e8>Official Name</color>**: DNA polymerase gamma 2, accessory subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11232|11232]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHN1|Q9UHN1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604983|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial chromosome|
|mitochondrial DNA metabolic process|
|mitochondrial DNA replication|
|mitochondrial genome maintenance|
|mitochondrion morphogenesis|
|DNA-directed DNA polymerase activity|
|mitochondrial nucleoid|
|DNA biosynthetic process|
|respiratory electron transport chain|
|DNA-dependent DNA replication|
|cellular respiration|
|electron transport chain|
|DNA replication|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|in utero embryonic development|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|DNA repair|
|cell part morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular component morphogenesis|
|oxidation-reduction process|
|embryo development|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.75|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.85|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.85|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.91|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.91|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.94|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.97|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.98|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.01|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.07|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.14|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.21|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.32|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.636|
|[[:human genes:s:selrc1|SELRC1]]|0.627|
|[[:human genes:a:aars2|AARS2]]|0.62|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.612|
|[[:human genes:t:tars2|TARS2]]|0.611|
|[[:human genes:s:sco2|SCO2]]|0.602|
|[[:human genes:q:qrsl1|QRSL1]]|0.601|
|[[:human genes:g:gfm1|GFM1]]|0.591|
|[[:human genes:p:pars2|PARS2]]|0.591|
|[[:human genes:p:polg|POLG]]|0.589|
|[[:human genes:y:yars2|YARS2]]|0.588|
|[[:human genes:l:lars2|LARS2]]|0.587|
|[[:human genes:m:mrps21|MRPS21]]|0.586|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.586|
|[[:human genes:n:ndufs2|NDUFS2]]|0.581|
|[[:human genes:w:wars2|WARS2]]|0.579|
|[[:human genes:n:ndufb11|NDUFB11]]|0.579|
|[[:human genes:v:vars2|VARS2]]|0.572|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.565|
|[[:human genes:e:ears2|EARS2]]|0.563|
|[[:human genes:r:rbfa|RBFA]]|0.563|
|[[:human genes:p:pet112|PET112]]|0.562|
|[[:human genes:d:dap3|DAP3]]|0.561|
|[[:human genes:s:ssbp1|SSBP1]]|0.556|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.552|
|[[:human genes:r:rpusd4|RPUSD4]]|0.552|
|[[:human genes:f:ftsj2|FTSJ2]]|0.552|
|[[:human genes:g:gatc|GATC]]|0.547|
|[[:human genes:c:c10orf2|C10orf2]]|0.546|
|[[:human genes:n:ndufa3|NDUFA3]]|0.545|
|[[:human genes:c:cox11|COX11]]|0.544|
|[[:human genes:p:pet117|PET117]]|0.542|
|[[:human genes:n:nubpl|NUBPL]]|0.541|
|[[:human genes:n:ndufa2|NDUFA2]]|0.541|
|[[:human genes:m:mrpl21|MRPL21]]|0.54|
|[[:human genes:r:rars2|RARS2]]|0.54|
|[[:human genes:g:grsf1|GRSF1]]|0.535|
|[[:human genes:c:cars2|CARS2]]|0.533|
|[[:human genes:a:acad9|ACAD9]]|0.533|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.531|
|[[:human genes:n:ndufc2|NDUFC2]]|0.53|
|[[:human genes:c:cox16|COX16]]|0.529|
|[[:human genes:m:mrps6|MRPS6]]|0.528|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.525|
|[[:human genes:c:coa3|COA3]]|0.524|
|[[:human genes:c:c12orf65|C12orf65]]|0.524|
|[[:human genes:n:ndufa11|NDUFA11]]|0.523|
|[[:human genes:m:mto1|MTO1]]|0.523|
|[[:human genes:f:fastkd5|FASTKD5]]|0.523|
|[[:human genes:n:ndufb5|NDUFB5]]|0.521|
|[[:human genes:m:mtg2|MTG2]]|0.521|
|[[:human genes:m:mrps16|MRPS16]]|0.511|
|[[:human genes:m:mrpl45|MRPL45]]|0.511|
|[[:human genes:w:wbscr16|WBSCR16]]|0.51|
|[[:human genes:g:gfm2|GFM2]]|0.51|
|[[:human genes:m:mrpl12|MRPL12]]|0.509|
|[[:human genes:c:c1qbp|C1QBP]]|0.508|
|[[:human genes:m:mtg1|MTG1]]|0.505|
|[[:human genes:m:mrps34|MRPS34]]|0.505|
|[[:human genes:b:bcs1l|BCS1L]]|0.504|
|[[:human genes:m:mrps5|MRPS5]]|0.504|
|[[:human genes:m:mettl17|METTL17]]|0.502|
|[[:human genes:n:ndufs7|NDUFS7]]|0.498|
|[[:human genes:t:tomm20|TOMM20]]|0.496|
|[[:human genes:t:tefm|TEFM]]|0.495|
|[[:human genes:m:mtif2|MTIF2]]|0.493|
|[[:human genes:m:malsu1|MALSU1]]|0.492|
|[[:human genes:m:mrps14|MRPS14]]|0.492|
|[[:human genes:m:mrpl53|MRPL53]]|0.489|
|[[:human genes:m:mrp63|MRP63]]|0.489|
|[[:human genes:n:ndufb9|NDUFB9]]|0.488|
|[[:human genes:m:mrpl23|MRPL23]]|0.488|
|[[:human genes:m:mrps23|MRPS23]]|0.488|
|[[:human genes:c:coa6|COA6]]|0.485|
|[[:human genes:e:ecsit|ECSIT]]|0.485|
|[[:human genes:m:mrps22|MRPS22]]|0.484|
|[[:human genes:m:mars2|MARS2]]|0.484|
|[[:human genes:p:polrmt|POLRMT]]|0.483|
|[[:human genes:m:mrpl47|MRPL47]]|0.481|
|[[:human genes:t:tfb1m|TFB1M]]|0.481|
|[[:human genes:n:ndufa1|NDUFA1]]|0.48|
|[[:human genes:d:dars2|DARS2]]|0.48|
|[[:human genes:c:coq2|COQ2]]|0.479|
|[[:human genes:n:ndufa8|NDUFA8]]|0.477|
|[[:human genes:a:aifm1|AIFM1]]|0.477|
|[[:human genes:f:fars2|FARS2]]|0.476|
|[[:human genes:m:mrps26|MRPS26]]|0.475|
|[[:human genes:r:rpusd3|RPUSD3]]|0.474|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.47|
|[[:human genes:n:ndufs8|NDUFS8]]|0.469|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.468|
|[[:human genes:m:mrps10|MRPS10]]|0.464|
|[[:human genes:c:c17orf89|C17orf89]]|0.462|
|[[:human genes:s:slc25a51|SLC25A51]]|0.461|
|[[:human genes:m:mrps24|MRPS24]]|0.461|
|[[:human genes:m:mipep|MIPEP]]|0.46|
|[[:human genes:m:mrps25|MRPS25]]|0.456|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.456|
|[[:human genes:p:pnpt1|PNPT1]]|0.456|
|[[:human genes:n:ndufa10|NDUFA10]]|0.455|
|[[:human genes:m:mrpl3|MRPL3]]|0.455|
|[[:human genes:m:mrps2|MRPS2]]|0.454|
|[[:human genes:m:mrps18a|MRPS18A]]|0.454|
|[[:human genes:m:mrpl42|MRPL42]]|0.453|
|[[:human genes:n:ndufb6|NDUFB6]]|0.452|
|[[:human genes:m:mrps35|MRPS35]]|0.451|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.45|
|[[:human genes:m:mterfd2|MTERFD2]]|0.449|
|[[:human genes:m:mtif3|MTIF3]]|0.448|
|[[:human genes:c:chchd1|CHCHD1]]|0.447|
|[[:human genes:n:ndufv2|NDUFV2]]|0.447|
|[[:human genes:t:tfam|TFAM]]|0.446|
|[[:human genes:m:mrpl43|MRPL43]]|0.445|
|[[:human genes:m:mrps27|MRPS27]]|0.445|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.445|
|[[:human genes:m:mrpl4|MRPL4]]|0.445|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.444|
|[[:human genes:m:mrpl2|MRPL2]]|0.444|
|[[:human genes:s:sars2|SARS2]]|0.444|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.443|
|[[:human genes:d:ddx28|DDX28]]|0.442|
|[[:human genes:p:pmvk|PMVK]]|0.44|
|[[:human genes:f:fastkd2|FASTKD2]]|0.44|
|[[:human genes:n:nsun4|NSUN4]]|0.44|
|[[:human genes:f:foxred1|FOXRED1]]|0.44|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.44|
|[[:human genes:c:coq6|COQ6]]|0.439|
|[[:human genes:m:mrps28|MRPS28]]|0.438|
|[[:human genes:d:dhx30|DHX30]]|0.438|
|[[:human genes:t:tmem261|TMEM261]]|0.438|
|[[:human genes:m:mrpl20|MRPL20]]|0.438|
|[[:human genes:m:mrps33|MRPS33]]|0.436|
|[[:human genes:h:hars2|HARS2]]|0.436|
|[[:human genes:m:mrpl15|MRPL15]]|0.436|
|[[:human genes:t:tomm6|TOMM6]]|0.436|
|[[:human genes:n:ndufa6|NDUFA6]]|0.435|
|[[:human genes:i:iba57|IBA57]]|0.435|
|[[:human genes:d:dhrsx|DHRSX]]|0.432|
|[[:human genes:m:mrpl44|MRPL44]]|0.432|
|[[:human genes:m:mrpl11|MRPL11]]|0.429|
|[[:human genes:n:ndufa13|NDUFA13]]|0.427|
|[[:human genes:s:slc25a3|SLC25A3]]|0.427|
|[[:human genes:n:ndufv1|NDUFV1]]|0.426|
|[[:human genes:m:mrps9|MRPS9]]|0.426|
|[[:human genes:c:cox15|COX15]]|0.424|
|[[:human genes:a:atp5sl|ATP5SL]]|0.423|
|[[:human genes:t:tmem242|TMEM242]]|0.422|
|[[:human genes:n:ndufb7|NDUFB7]]|0.422|
|[[:human genes:m:mrps12|MRPS12]]|0.42|
|[[:human genes:m:mrps7|MRPS7]]|0.417|
|[[:human genes:n:ndufb10|NDUFB10]]|0.415|
|[[:human genes:t:tufm|TUFM]]|0.414|
|[[:human genes:p:pet100|PET100]]|0.413|
|[[:human genes:e:eral1|ERAL1]]|0.413|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.413|
|[[:human genes:n:ndufb2|NDUFB2]]|0.41|
|[[:human genes:m:mrpl38|MRPL38]]|0.41|
|[[:human genes:n:ndufc1|NDUFC1]]|0.41|
|[[:human genes:c:cox6c|COX6C]]|0.409|
|[[:human genes:m:mcat|MCAT]]|0.408|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.407|
|[[:human genes:m:mtpap|MTPAP]]|0.406|
|[[:human genes:p:pgm3|PGM3]]|0.405|
|[[:human genes:n:ndufs5|NDUFS5]]|0.404|
|[[:human genes:m:mterfd1|MTERFD1]]|0.404|
|[[:human genes:m:mrpl35|MRPL35]]|0.403|
|[[:human genes:n:ndufs1|NDUFS1]]|0.403|
|[[:human genes:m:mrps11|MRPS11]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLG2 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>