======= POLK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLK
  * **<color #00a2e8>Official Name</color>**: DNA polymerase kappa
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51426|51426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBT6|Q9UBT6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IMS C|
|IMS|
|IMS HHH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|site of DNA damage|
|error-prone translesion synthesis|
|nucleotide-excision repair, DNA gap filling|
|DNA-directed DNA polymerase activity|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|damaged DNA binding|
|transcription-coupled nucleotide-excision repair|
|cellular response to UV|
|DNA biosynthetic process|
|nucleotide-excision repair|
|cellular response to light stimulus|
|response to UV|
|cellular response to radiation|
|DNA replication|
|nuclear body|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to radiation|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.08|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.95|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.86|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.7|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9345
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLK Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>