======= POLR2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2C
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5432|5432]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19387|P19387]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol L|
|RNA pol A bac|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II activity|
|RNA polymerase II, core complex|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|positive regulation of viral transcription|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|fibroblast growth factor receptor signaling pathway|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|positive regulation of viral process|
|cellular response to fibroblast growth factor stimulus|
|nucleotide-excision repair|
|response to fibroblast growth factor|
|regulation of gene silencing|
|stem cell population maintenance|
|maintenance of cell number|
|microtubule cytoskeleton|
|protein dimerization activity|
|transcription initiation from RNA polymerase II promoter|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|DNA binding|
|response to endogenous stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.14|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.95|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.91|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.88|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.82|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.79|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.76|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.71|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.73|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.76|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.77|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.79|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.01|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.11|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.32|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.459|
|[[:human genes:p:prim1|PRIM1]]|0.448|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2C Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>