======= POLR2J2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2J2
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit J2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=246721|246721]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZM3|Q9GZM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2J2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2J2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609881|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol L|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II activity|
|RNA polymerase II, core complex|
|DNA-directed 5-3 RNA polymerase activity|
|protein dimerization activity|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.43|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.26|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.1|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.06|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.99|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.74|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.76|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.84|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.85|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.96|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.03|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.11|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.12|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.19|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.22|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.26|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.38|
|[[:results:exp453|B02 10μM R08 exp453]]|2.39|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.446|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.437|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.418|
|[[:human genes:o:osbp|OSBP]]|0.411|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.411|
|[[:human genes:i:igfn1|IGFN1]]|0.41|
|[[:human genes:t:ticrr|TICRR]]|0.41|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.403|
|[[:human genes:t:tspy8|TSPY8]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2J2 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>