======= POLRMT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLRMT
  * **<color #00a2e8>Official Name</color>**: RNA polymerase mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5442|5442]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00411|O00411]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLRMT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLRMT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. {ECO:0000269|PubMed:21278163}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial DNA-directed RNA polymerase complex|
|mitochondrial promoter sequence-specific DNA binding|
|transcription initiation from mitochondrial promoter|
|mitochondrial transcription|
|DNA-directed 5-3 RNA polymerase activity|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|mitochondrial gene expression|
|DNA-templated transcription, initiation|
|mitochondrial matrix|
|sequence-specific DNA binding|
|mitochondrion organization|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.88|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.24|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pars2|PARS2]]|0.592|
|[[:human genes:m:mrps34|MRPS34]]|0.587|
|[[:human genes:m:mettl17|METTL17]]|0.586|
|[[:human genes:m:mrps6|MRPS6]]|0.58|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.579|
|[[:human genes:n:nars2|NARS2]]|0.571|
|[[:human genes:t:tars2|TARS2]]|0.566|
|[[:human genes:q:qrsl1|QRSL1]]|0.562|
|[[:human genes:m:mrps27|MRPS27]]|0.558|
|[[:human genes:a:acad9|ACAD9]]|0.554|
|[[:human genes:m:mrpl47|MRPL47]]|0.551|
|[[:human genes:m:mrps21|MRPS21]]|0.55|
|[[:human genes:n:ndufb11|NDUFB11]]|0.55|
|[[:human genes:d:dars2|DARS2]]|0.542|
|[[:human genes:m:mrpl21|MRPL21]]|0.539|
|[[:human genes:y:yars2|YARS2]]|0.536|
|[[:human genes:m:mrp63|MRP63]]|0.536|
|[[:human genes:p:polg|POLG]]|0.535|
|[[:human genes:e:ears2|EARS2]]|0.527|
|[[:human genes:c:chchd1|CHCHD1]]|0.519|
|[[:human genes:p:pet117|PET117]]|0.518|
|[[:human genes:f:ftsj2|FTSJ2]]|0.517|
|[[:human genes:m:mrpl3|MRPL3]]|0.517|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.513|
|[[:human genes:s:selrc1|SELRC1]]|0.513|
|[[:human genes:a:aars2|AARS2]]|0.512|
|[[:human genes:d:dap3|DAP3]]|0.512|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.51|
|[[:human genes:l:lars2|LARS2]]|0.507|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.507|
|[[:human genes:m:mrpl23|MRPL23]]|0.506|
|[[:human genes:s:sco2|SCO2]]|0.503|
|[[:human genes:m:mrps2|MRPS2]]|0.502|
|[[:human genes:c:coa3|COA3]]|0.498|
|[[:human genes:r:rbfa|RBFA]]|0.494|
|[[:human genes:m:mars2|MARS2]]|0.492|
|[[:human genes:n:ndufa3|NDUFA3]]|0.492|
|[[:human genes:p:ptcd3|PTCD3]]|0.491|
|[[:human genes:m:mrps5|MRPS5]]|0.49|
|[[:human genes:m:mrps26|MRPS26]]|0.489|
|[[:human genes:v:vars2|VARS2]]|0.489|
|[[:human genes:n:ndufb9|NDUFB9]]|0.485|
|[[:human genes:m:mrpl42|MRPL42]]|0.485|
|[[:human genes:r:rars2|RARS2]]|0.485|
|[[:human genes:m:mtg2|MTG2]]|0.484|
|[[:human genes:m:mrps14|MRPS14]]|0.484|
|[[:human genes:s:sars2|SARS2]]|0.484|
|[[:human genes:p:polg2|POLG2]]|0.483|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.483|
|[[:human genes:g:gfm2|GFM2]]|0.478|
|[[:human genes:g:gfm1|GFM1]]|0.478|
|[[:human genes:m:mrpl4|MRPL4]]|0.474|
|[[:human genes:n:ndufs2|NDUFS2]]|0.472|
|[[:human genes:h:hars2|HARS2]]|0.471|
|[[:human genes:p:pet112|PET112]]|0.469|
|[[:human genes:d:ddx28|DDX28]]|0.469|
|[[:human genes:c:c10orf2|C10orf2]]|0.469|
|[[:human genes:m:mrpl53|MRPL53]]|0.466|
|[[:human genes:m:mrps10|MRPS10]]|0.465|
|[[:human genes:r:rpusd4|RPUSD4]]|0.463|
|[[:human genes:m:mrps9|MRPS9]]|0.463|
|[[:human genes:m:mrpl45|MRPL45]]|0.462|
|[[:human genes:s:slc25a51|SLC25A51]]|0.46|
|[[:human genes:f:fastkd5|FASTKD5]]|0.459|
|[[:human genes:n:ndufa1|NDUFA1]]|0.458|
|[[:human genes:t:tefm|TEFM]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.456|
|[[:human genes:r:rpusd3|RPUSD3]]|0.455|
|[[:human genes:b:bcs1l|BCS1L]]|0.452|
|[[:human genes:t:tomm20|TOMM20]]|0.452|
|[[:human genes:m:mrpl22|MRPL22]]|0.452|
|[[:human genes:m:mrpl12|MRPL12]]|0.451|
|[[:human genes:m:mto1|MTO1]]|0.451|
|[[:human genes:c:cox16|COX16]]|0.451|
|[[:human genes:m:mrpl17|MRPL17]]|0.451|
|[[:human genes:m:malsu1|MALSU1]]|0.449|
|[[:human genes:m:mrps18a|MRPS18A]]|0.449|
|[[:human genes:m:mrpl9|MRPL9]]|0.449|
|[[:human genes:m:mrpl15|MRPL15]]|0.448|
|[[:human genes:m:mrps11|MRPS11]]|0.448|
|[[:human genes:n:ndufb6|NDUFB6]]|0.446|
|[[:human genes:c:cars2|CARS2]]|0.445|
|[[:human genes:m:mtg1|MTG1]]|0.444|
|[[:human genes:m:mrpl20|MRPL20]]|0.444|
|[[:human genes:c:c12orf65|C12orf65]]|0.443|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.443|
|[[:human genes:p:pgm3|PGM3]]|0.443|
|[[:human genes:c:cox6b1|COX6B1]]|0.442|
|[[:human genes:n:ndufc2|NDUFC2]]|0.442|
|[[:human genes:c:cox15|COX15]]|0.442|
|[[:human genes:g:grsf1|GRSF1]]|0.442|
|[[:human genes:w:wars2|WARS2]]|0.441|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.441|
|[[:human genes:s:ssbp1|SSBP1]]|0.44|
|[[:human genes:f:fastkd2|FASTKD2]]|0.44|
|[[:human genes:f:fars2|FARS2]]|0.438|
|[[:human genes:n:ndufc1|NDUFC1]]|0.438|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.438|
|[[:human genes:a:atp5sl|ATP5SL]]|0.437|
|[[:human genes:p:pnpt1|PNPT1]]|0.436|
|[[:human genes:m:mrps16|MRPS16]]|0.436|
|[[:human genes:m:mterfd2|MTERFD2]]|0.434|
|[[:human genes:n:ndufa8|NDUFA8]]|0.433|
|[[:human genes:m:mrpl39|MRPL39]]|0.432|
|[[:human genes:t:trub2|TRUB2]]|0.431|
|[[:human genes:t:tfb1m|TFB1M]]|0.43|
|[[:human genes:m:mtif2|MTIF2]]|0.429|
|[[:human genes:m:mrpl11|MRPL11]]|0.428|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.428|
|[[:human genes:n:nsun4|NSUN4]]|0.427|
|[[:human genes:a:aifm1|AIFM1]]|0.426|
|[[:human genes:m:mrps12|MRPS12]]|0.425|
|[[:human genes:c:cox11|COX11]]|0.421|
|[[:human genes:m:mterfd1|MTERFD1]]|0.421|
|[[:human genes:m:mrpl44|MRPL44]]|0.421|
|[[:human genes:m:mrps22|MRPS22]]|0.418|
|[[:human genes:i:iba57|IBA57]]|0.418|
|[[:human genes:w:wbscr16|WBSCR16]]|0.418|
|[[:human genes:m:mrpl28|MRPL28]]|0.418|
|[[:human genes:n:ndufv1|NDUFV1]]|0.418|
|[[:human genes:m:mrpl41|MRPL41]]|0.417|
|[[:human genes:m:mrps25|MRPS25]]|0.417|
|[[:human genes:c:coa6|COA6]]|0.416|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.415|
|[[:human genes:d:dhx30|DHX30]]|0.415|
|[[:human genes:m:mtpap|MTPAP]]|0.414|
|[[:human genes:t:tfb2m|TFB2M]]|0.413|
|[[:human genes:m:mrpl37|MRPL37]]|0.411|
|[[:human genes:m:mipep|MIPEP]]|0.409|
|[[:human genes:t:tmem261|TMEM261]]|0.409|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.408|
|[[:human genes:s:slc25a52|SLC25A52]]|0.405|
|[[:human genes:n:ndufb5|NDUFB5]]|0.405|
|[[:human genes:m:mrpl43|MRPL43]]|0.405|
|[[:human genes:n:ndufb7|NDUFB7]]|0.404|
|[[:human genes:n:ndufa11|NDUFA11]]|0.403|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.403|
|[[:human genes:m:mrpl35|MRPL35]]|0.401|
|[[:human genes:m:mrps35|MRPS35]]|0.4|
|[[:human genes:m:mcat|MCAT]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|1/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|3/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 508
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLRMT Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>