======= PON1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PON1
  * **<color #00a2e8>Official Name</color>**: paraoxonase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5444|5444]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27169|P27169]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PON1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PON1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/168820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. {ECO:0000269|PubMed:10479665, ECO:0000269|PubMed:15772423}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SGL|
|Arylesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aryldialkylphosphatase activity|
|negative regulation of plasma lipoprotein oxidation|
|regulation of plasma lipoprotein oxidation|
|acyl-L-homoserine-lactone lactonohydrolase activity|
|response to fluoride|
|arylesterase activity|
|spherical high-density lipoprotein particle|
|positive regulation of cholesterol efflux|
|lipoxygenase pathway|
|high-density lipoprotein particle|
|positive regulation of sterol transport|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|regulation of cholesterol transport|
|regulation of sterol transport|
|positive regulation of lipid transport|
|phosphatidylcholine metabolic process|
|positive regulation of lipid localization|
|response to fatty acid|
|phospholipid binding|
|regulation of lipid transport|
|positive regulation of transporter activity|
|icosanoid metabolic process|
|cholesterol metabolic process|
|organophosphate catabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|regulation of lipid localization|
|blood microparticle|
|fatty acid derivative metabolic process|
|positive regulation of binding|
|ammonium ion metabolic process|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|regulation of transporter activity|
|glycerophospholipid metabolic process|
|dephosphorylation|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to acid chemical|
|phospholipid metabolic process|
|regulation of binding|
|glycerolipid metabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|intracellular membrane-bounded organelle|
|negative regulation of cellular component organization|
|calcium ion binding|
|response to lipid|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|positive regulation of transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|response to oxygen-containing compound|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PON1 Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>