======= POU3F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU3F2
  * **<color #00a2e8>Official Name</color>**: POU class 3 homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5454|5454]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20265|P20265]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU3F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU3F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600494|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity). {ECO:0000250|UniProtKB:P31360, ECO:0000250|UniProtKB:P56222}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pou|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurohypophysis development|
|forebrain ventricular zone progenitor cell division|
|hypothalamus cell differentiation|
|hypothalamus development|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|cell proliferation in forebrain|
|cerebral cortex radially oriented cell migration|
|Schwann cell development|
|positive regulation of multicellular organism growth|
|neuron fate specification|
|Schwann cell differentiation|
|astrocyte development|
|pituitary gland development|
|cerebral cortex cell migration|
|astrocyte differentiation|
|telencephalon cell migration|
|forebrain cell migration|
|neuron fate commitment|
|regulation of multicellular organism growth|
|peripheral nervous system development|
|neural precursor cell proliferation|
|diencephalon development|
|cell fate specification|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|limbic system development|
|cerebral cortex development|
|endocrine system development|
|glial cell differentiation|
|positive regulation of developmental growth|
|pallium development|
|regulation of axonogenesis|
|transcription factor complex|
|gliogenesis|
|cell fate commitment|
|telencephalon development|
|positive regulation of growth|
|transcription coactivator activity|
|regulation of cell morphogenesis involved in differentiation|
|regulation of developmental growth|
|forebrain development|
|gland development|
|epidermis development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of cell morphogenesis|
|cell division|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell population proliferation|
|regulation of neuron differentiation|
|regulation of growth|
|DNA-binding transcription factor activity|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.72|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.71|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.8|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9449
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU3F2 Expression in NALM6 Cells: -0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>