======= POU4F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POU4F2
  * **<color #00a2e8>Official Name</color>**: POU class 4 homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5458|5458]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12837|Q12837]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POU4F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POU4F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5'-AT[A/T]A[T/A]T[A/T]A-3' in promoter of target genes (PubMed:19266028, PubMed:23805044). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina. Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes. Plays a role in TNFSF11- mediated terminal osteoclast differentiation. Binds chromatin at promoter region of target genes (By similarity). {ECO:0000250|UniProtKB:Q63934, ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:23805044}. Isoform 2: Acts either as a transcriptional activator or repressor (PubMed:23805044). Stimulates the promoter activity of the neuronal nicotinic acetylcholine receptor alpha CHRNA2. Negatively regulates the apoptosis regulator BAX promoter activity. Inhibits promoter activity of the neuronal intermediate filament protein alpha-internexin INA gene. Plays a role in the regulation of breast cancer cell growth by promoting transcription activation as well as repression of specific target genes. Involved in tumor breast progression and invasion (By similarity). Inhibits the promoter activity of the GTP-binding protein RIT2 gene containing the octamer binding site in retinal ganglion cells (PubMed:23805044). Plays also a role either as transcriptional coactivator or corepressor. Transcriptional coactivator cooperating with transcription factors TP53 to potentiate transcriptional activation of BAX promoter activity, and hence increases neuronal cell apoptosis. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to the octamer motif. Acts also as a transcriptional coactivator via its interaction with the transcription factor ESR1 (By similarity). {ECO:0000250|UniProtKB:Q63934, ECO:0000269|PubMed:23805044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pou|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of retina development in camera-type eye|
|negative regulation of amacrine cell differentiation|
|negative regulation of neural retina development|
|negative regulation of adipose tissue development|
|regulation of amacrine cell differentiation|
|regulation of retinal ganglion cell axon guidance|
|regulation of neural retina development|
|regulation of retina development in camera-type eye|
|dorsal root ganglion development|
|regulation of adipose tissue development|
|positive regulation of cardiac muscle cell apoptotic process|
|positive regulation of striated muscle cell apoptotic process|
|ganglion development|
|retinal ganglion cell axon guidance|
|intracellular estrogen receptor signaling pathway|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of osteoclast differentiation|
|positive regulation of muscle cell apoptotic process|
|nuclear euchromatin|
|axon extension|
|cellular response to estradiol stimulus|
|positive regulation of glucose import|
|regulation of cardiac muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|positive regulation of axon extension|
|positive regulation of glucose transmembrane transport|
|regulation of axon guidance|
|promoter-specific chromatin binding|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|neuromuscular process controlling balance|
|regulation of transcription regulatory region DNA binding|
|positive regulation of myeloid leukocyte differentiation|
|regulation of glucose import|
|positive regulation of DNA binding|
|neuron projection extension|
|regulation of osteoclast differentiation|
|p53 binding|
|regulation of muscle cell apoptotic process|
|intracellular steroid hormone receptor signaling pathway|
|regulation of glucose transmembrane transport|
|positive regulation of axonogenesis|
|developmental cell growth|
|cell growth|
|positive regulation of myeloid cell differentiation|
|regulation of axon extension|
|neuromuscular process|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|regulation of myeloid leukocyte differentiation|
|steroid hormone mediated signaling pathway|
|signal transduction by p53 class mediator|
|regulation of DNA binding|
|response to estradiol|
|retina development in camera-type eye|
|sensory perception of sound|
|positive regulation of leukocyte differentiation|
|intrinsic apoptotic signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to insulin stimulus|
|intracellular receptor signaling pathway|
|positive regulation of cell growth|
|sensory perception of mechanical stimulus|
|hormone-mediated signaling pathway|
|positive regulation of developmental growth|
|positive regulation of binding|
|regulation of signal transduction by p53 class mediator|
|regulation of cell size|
|regulation of axonogenesis|
|cellular response to steroid hormone stimulus|
|positive regulation of hemopoiesis|
|positive regulation of transmembrane transport|
|transcription factor complex|
|regulation of chemotaxis|
|cellular response to oxygen levels|
|negative regulation of neuron differentiation|
|regulation of myeloid cell differentiation|
|response to insulin|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of growth|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|regulation of leukocyte differentiation|
|positive regulation of neuron projection development|
|apoptotic signaling pathway|
|transcription coactivator activity|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|camera-type eye development|
|cellular response to peptide|
|response to steroid hormone|
|regulation of developmental growth|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|MAPK cascade|
|axonogenesis|
|regulation of binding|
|regulation of cellular component size|
|response to oxygen levels|
|positive regulation of cell projection organization|
|developmental growth|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|nuclear speck|
|axon development|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of anatomical structure size|
|cell part morphogenesis|
|cellular response to lipid|
|heart development|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|spermatogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|male gamete generation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|sensory perception|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POU4F2 Expression in NALM6 Cells: -1.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>