======= PPARGC1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPARGC1A
  * **<color #00a2e8>Official Name</color>**: PPARG coactivator 1 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10891|10891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBK2|Q9UBK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPARGC1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPARGC1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604517|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glomerular visceral epithelial cell apoptotic process|
|cellular response to resveratrol|
|positive regulation of mitochondrial DNA metabolic process|
|cellular response to nitrite|
|interfibrillar mitochondrion|
|response to resveratrol|
|subsarcolemmal mitochondrion|
|response to nitrite|
|regulation of glomerular visceral epithelial cell apoptotic process|
|positive regulation of progesterone biosynthetic process|
|response to metformin|
|response to methionine|
|regulation of mitochondrial DNA metabolic process|
|negative regulation of mitochondrial fission|
|response to electrical stimulus involved in regulation of muscle adaptation|
|response to norepinephrine|
|regulation of progesterone biosynthetic process|
|cellular response to ionomycin|
|response to ionomycin|
|response to stilbenoid|
|cellular response to ether|
|cellular response to fructose stimulus|
|flavone metabolic process|
|skeletal muscle atrophy|
|striated muscle atrophy|
|response to fructose|
|cytosolic ribosome|
|muscle atrophy|
|positive regulation of cellular respiration|
|cellular response to potassium ion|
|cellular response to caffeine|
|positive regulation of hormone biosynthetic process|
|cellular response to follicle-stimulating hormone stimulus|
|skeletal muscle adaptation|
|peroxisome proliferator activated receptor binding|
|response to ether|
|positive regulation of ATP biosynthetic process|
|negative regulation of glycolytic process|
|response to leucine|
|galactose metabolic process|
|positive regulation of gluconeogenesis|
|cellular response to purine-containing compound|
|positive regulation of fatty acid oxidation|
|flavonoid metabolic process|
|positive regulation of hormone metabolic process|
|response to stimulus involved in regulation of muscle adaptation|
|response to potassium ion|
|apical dendrite|
|cellular response to thyroid hormone stimulus|
|regulation of ketone biosynthetic process|
|response to follicle-stimulating hormone|
|response to epinephrine|
|response to caffeine|
|response to diuretic|
|positive regulation of steroid biosynthetic process|
|regulation of ATP biosynthetic process|
|negative regulation of purine nucleotide metabolic process|
|cellular response to gonadotropin stimulus|
|negative regulation of nucleotide metabolic process|
|adaptive thermogenesis|
|cellular response to reactive nitrogen species|
|nuclear receptor binding|
|negative regulation of smooth muscle cell migration|
|positive regulation of purine nucleotide biosynthetic process|
|positive regulation of nucleotide biosynthetic process|
|regulation of mitochondrial fission|
|response to muscle activity|
|negative regulation of ATP metabolic process|
|response to thyroid hormone|
|striated muscle adaptation|
|regulation of hormone biosynthetic process|
|response to dietary excess|
|positive regulation of steroid metabolic process|
|androgen metabolic process|
|brown fat cell differentiation|
|response to gonadotropin|
|regulation of cellular respiration|
|temperature homeostasis|
|regulation of fatty acid oxidation|
|nuclear euchromatin|
|positive regulation of histone acetylation|
|cellular response to interleukin-6|
|positive regulation of epithelial cell apoptotic process|
|muscle adaptation|
|positive regulation of peptidyl-lysine acetylation|
|energy homeostasis|
|positive regulation of fatty acid metabolic process|
|cellular response to alkaloid|
|cellular response to estradiol stimulus|
|response to interleukin-6|
|adipose tissue development|
|androgen receptor signaling pathway|
|regulation of NMDA receptor activity|
|positive regulation of glucose metabolic process|
|regulation of hormone metabolic process|
|regulation of purine nucleotide biosynthetic process|
|mitochondrion disassembly|
|alpha-tubulin binding|
|autophagy of mitochondrion|
|regulation of nucleotide biosynthetic process|
|positive regulation of protein acetylation|
|negative regulation of cellular carbohydrate metabolic process|
|estrogen receptor binding|
|response to electrical stimulus|
|gluconeogenesis|
|androgen receptor binding|
|positive regulation of ATP metabolic process|
|positive regulation of nucleotide metabolic process|
|regulation of gluconeogenesis|
|positive regulation of purine nucleotide metabolic process|
|negative regulation of smooth muscle cell proliferation|
|hexose biosynthetic process|
|negative regulation of carbohydrate metabolic process|
|response to ischemia|
|response to cold|
|promoter-specific chromatin binding|
|monosaccharide biosynthetic process|
|negative regulation of mitochondrion organization|
|cellular response to fatty acid|
|regulation of histone acetylation|
|positive regulation of cellular carbohydrate metabolic process|
|negative regulation of signaling receptor activity|
|regulation of smooth muscle cell migration|
|circadian regulation of gene expression|
|regulation of peptidyl-lysine acetylation|
|pigment metabolic process|
|regulation of glutamate receptor signaling pathway|
|organelle disassembly|
|nuclear receptor transcription coactivator activity|
|response to activity|
|intracellular steroid hormone receptor signaling pathway|
|cellular response to glucose stimulus|
|positive regulation of muscle tissue development|
|regulation of protein acetylation|
|chromatin DNA binding|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|regulation of neurotransmitter receptor activity|
|fatty acid oxidation|
|lipid oxidation|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|positive regulation of lipid biosynthetic process|
|regulation of epithelial cell apoptotic process|
|cellular response to carbohydrate stimulus|
|transcription coregulator activity|
|response to fatty acid|
|positive regulation of smooth muscle cell proliferation|
|regulation of muscle adaptation|
|regulation of fatty acid metabolic process|
|regulation of steroid biosynthetic process|
|regulation of carbohydrate catabolic process|
|cellular glucose homeostasis|
|negative regulation of small molecule metabolic process|
|positive regulation of histone modification|
|regulation of carbohydrate biosynthetic process|
|positive regulation of cold-induced thermogenesis|
|PML body|
|cerebellum development|
|positive regulation of chromatin organization|
|response to monoamine|
|fat cell differentiation|
|response to catecholamine|
|respiratory electron transport chain|
|metencephalon development|
|digestion|
|response to alkaloid|
|regulation of glucose metabolic process|
|glucose metabolic process|
|regulation of steroid metabolic process|
|regulation of circadian rhythm|
|response to amino acid|
|positive regulation of mitochondrion organization|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|steroid hormone mediated signaling pathway|
|regulation of ATP metabolic process|
|cellular hormone metabolic process|
|carbohydrate biosynthetic process|
|regulation of smooth muscle cell proliferation|
|regulation of muscle tissue development|
|response to estradiol|
|response to glucose|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|circadian rhythm|
|positive regulation of lipid metabolic process|
|response to hexose|
|regulation of cold-induced thermogenesis|
|negative regulation of neuron apoptotic process|
|regulation of histone modification|
|response to monosaccharide|
|hindbrain development|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|response to transforming growth factor beta|
|intracellular receptor signaling pathway|
|cellular respiration|
|hormone-mediated signaling pathway|
|response to carbohydrate|
|regulation of cation channel activity|
|regulation of cellular ketone metabolic process|
|regulation of signaling receptor activity|
|positive regulation of chromosome organization|
|transcription initiation from RNA polymerase II promoter|
|response to temperature stimulus|
|protein stabilization|
|regulation of mitochondrion organization|
|electron transport chain|
|cellular response to lipopolysaccharide|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|cellular response to hypoxia|
|regulation of chromatin organization|
|cellular response to molecule of bacterial origin|
|cellular response to metal ion|
|response to starvation|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|monosaccharide metabolic process|
|hormone metabolic process|
|lipid modification|
|regulation of carbohydrate metabolic process|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cellular response to acid chemical|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|cellular response to biotic stimulus|
|DNA-templated transcription, initiation|
|cellular response to inorganic substance|
|connective tissue development|
|energy derivation by oxidation of organic compounds|
|regulation of muscle system process|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|regulation of ion transmembrane transporter activity|
|negative regulation of cell migration|
|steroid metabolic process|
|positive regulation of DNA-binding transcription factor activity|
|process utilizing autophagic mechanism|
|autophagy|
|response to tumor necrosis factor|
|regulation of transmembrane transporter activity|
|negative regulation of cell motility|
|rhythmic process|
|regulation of transporter activity|
|aging|
|transcription coactivator activity|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|muscle system process|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of neuron death|
|response to lipopolysaccharide|
|negative regulation of locomotion|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|response to steroid hormone|
|transcription factor binding|
|regulation of cation transmembrane transport|
|response to hypoxia|
|response to acid chemical|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|response to metal ion|
|neuronal cell body|
|negative regulation of organelle organization|
|response to oxygen levels|
|forebrain development|
|response to oxidative stress|
|regulation of lipid metabolic process|
|RNA splicing|
|cellular component disassembly|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|sequence-specific DNA binding|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|regulation of DNA-binding transcription factor activity|
|mitochondrion organization|
|negative regulation of phosphorylation|
|carbohydrate metabolic process|
|mRNA processing|
|regulation of ion transmembrane transport|
|transcription by RNA polymerase II|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to toxic substance|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|small molecule biosynthetic process|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|response to bacterium|
|mRNA metabolic process|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|brain development|
|cellular chemical homeostasis|
|head development|
|regulation of cell migration|
|response to lipid|
|RNA processing|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.442|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPARGC1A Expression in NALM6 Cells: 1.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>