======= PPARGC1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPARGC1B
  * **<color #00a2e8>Official Name</color>**: PPARG coactivator 1 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=133522|133522]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YN6|Q86YN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPARGC1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPARGC1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608886|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|AF-2 domain binding|
|positive regulation of alkaline phosphatase activity|
|bone trabecula formation|
|regulation of alkaline phosphatase activity|
|bone trabecula morphogenesis|
|mitochondrial transcription|
|positive regulation of bone remodeling|
|positive regulation of bone resorption|
|intracellular estrogen receptor signaling pathway|
|trabecula formation|
|positive regulation of osteoclast differentiation|
|positive regulation of tissue remodeling|
|positive regulation of phosphatase activity|
|mediator complex|
|mitochondrial RNA metabolic process|
|regulation of bone resorption|
|estrogen receptor binding|
|trabecula morphogenesis|
|regulation of bone remodeling|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of dephosphorylation|
|nuclear receptor transcription coactivator activity|
|regulation of osteoclast differentiation|
|intracellular steroid hormone receptor signaling pathway|
|regulation of tissue remodeling|
|transcription coregulator activity|
|positive regulation of myeloid cell differentiation|
|positive regulation of cold-induced thermogenesis|
|response to cAMP|
|regulation of myeloid leukocyte differentiation|
|steroid hormone mediated signaling pathway|
|cellular response to reactive oxygen species|
|response to organophosphorus|
|mitochondrial gene expression|
|regulation of cold-induced thermogenesis|
|response to glucocorticoid|
|positive regulation of leukocyte differentiation|
|response to purine-containing compound|
|response to corticosteroid|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of phosphatase activity|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|response to reactive oxygen species|
|regulation of dephosphorylation|
|regulation of myeloid cell differentiation|
|skeletal system morphogenesis|
|cellular response to oxidative stress|
|actin filament organization|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|regulation of leukocyte differentiation|
|response to steroid hormone|
|transcription factor binding|
|response to oxidative stress|
|regulation of DNA-binding transcription factor activity|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|skeletal system development|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|actin filament-based process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of hydrolase activity|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.94|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.71|
|[[:results:exp302|35°C R06 exp302]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 128/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|7/28|
|bone|7/25|
|breast|5/33|
|central nervous system|11/56|
|cervix|3/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|3/21|
|liver|1/20|
|lung|15/75|
|lymphocyte|0/14|
|ovary|5/26|
|pancreas|2/24|
|peripheral nervous system|6/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPARGC1B Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>