======= PPIF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIF
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10105|10105]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30405|P30405]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604486|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. {ECO:0000269|PubMed:19228691, ECO:0000269|PubMed:22726440, ECO:0000269|PubMed:26387735}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of proton-transporting ATPase activity, rotational mechanism|
|negative regulation of oxidative phosphorylation uncoupler activity|
|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|
|mitochondrial permeability transition pore complex|
|regulation of oxidative phosphorylation uncoupler activity|
|negative regulation of oxidative phosphorylation|
|mitochondrial proton-transporting ATP synthase complex|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|cellular response to arsenic-containing substance|
|negative regulation of release of cytochrome c from mitochondria|
|negative regulation of ATPase activity|
|positive regulation of mitochondrial membrane permeability|
|regulation of proton transport|
|necroptotic process|
|positive regulation of membrane permeability|
|cyclosporin A binding|
|negative regulation of ATP metabolic process|
|programmed necrotic cell death|
|regulation of necrotic cell death|
|positive regulation of release of cytochrome c from mitochondria|
|necrotic cell death|
|regulation of oxidative phosphorylation|
|response to arsenic-containing substance|
|protein refolding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|regulation of release of cytochrome c from mitochondria|
|response to ischemia|
|negative regulation of mitochondrion organization|
|apoptotic mitochondrial changes|
|peptidyl-proline modification|
|cellular response to hydrogen peroxide|
|regulation of mitochondrial membrane permeability|
|negative regulation of transporter activity|
|regulation of membrane permeability|
|regulation of ATPase activity|
|negative regulation of cation transmembrane transport|
|cellular response to calcium ion|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of ion transmembrane transport|
|positive regulation of mitochondrion organization|
|negative regulation of transmembrane transport|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of ATP metabolic process|
|mitochondrial membrane organization|
|cellular response to reactive oxygen species|
|unfolded protein binding|
|negative regulation of ion transport|
|response to calcium ion|
|regulation of generation of precursor metabolites and energy|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|cellular response to metal ion|
|response to reactive oxygen species|
|cellular response to toxic substance|
|mitochondrial transport|
|cellular response to inorganic substance|
|negative regulation of apoptotic signaling pathway|
|protein folding|
|cellular response to oxidative stress|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|response to antibiotic|
|regulation of cation transmembrane transport|
|mitochondrial matrix|
|response to metal ion|
|negative regulation of organelle organization|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|mitochondrion organization|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|negative regulation of catalytic activity|
|membrane organization|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIF Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>