======= PPIL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIL1
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51645|51645]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3C6|Q9Y3C6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. {ECO:0000269|PubMed:16595688}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclosporin A binding|
|U2-type catalytic step 2 spliceosome|
|disordered domain specific binding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|catalytic step 2 spliceosome|
|protein folding|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|peptidyl-amino acid modification|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.79|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.73|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.55|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.55|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.54|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.47|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.43|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.41|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.34|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.32|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.32|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.13|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.07|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.07|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.05|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.02|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.97|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.94|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.88|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.85|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.84|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.81|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.79|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.79|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.77|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.74|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.73|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.71|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.71|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.71|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.71|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:snrnp40|SNRNP40]]|0.464|
|[[:human genes:r:rbm26|RBM26]]|0.413|
|[[:human genes:p:psme3|PSME3]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 197/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|9/28|
|bone|1/26|
|breast|10/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|3/21|
|liver|5/20|
|lung|23/75|
|lymphocyte|8/16|
|ovary|11/26|
|pancreas|7/24|
|peripheral nervous system|7/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2376
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIL1 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>