======= PPP1R1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R1B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory inhibitor subunit 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84152|84152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UD71|Q9UD71]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604399|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of protein-phosphatase 1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DARPP-32|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|D4 dopamine receptor binding|
|D5 dopamine receptor binding|
|D3 dopamine receptor binding|
|negative regulation of female receptivity|
|D2 dopamine receptor binding|
|dendritic spine neck|
|regulation of female receptivity|
|female mating behavior|
|D1 dopamine receptor binding|
|dendritic spine head|
|behavioral response to cocaine|
|mating behavior|
|protein kinase inhibitor activity|
|reproductive behavior|
|response to amphetamine|
|mating|
|protein phosphatase regulator activity|
|response to morphine|
|response to isoquinoline alkaloid|
|protein phosphatase inhibitor activity|
|response to amine|
|visual learning|
|response to nicotine|
|response to bronchodilator|
|visual behavior|
|response to cocaine|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|associative learning|
|response to anesthetic|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|response to alkaloid|
|memory|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|adult behavior|
|learning|
|regulation of phosphatase activity|
|response to ammonium ion|
|locomotory behavior|
|regulation of dephosphorylation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|learning or memory|
|negative regulation of transferase activity|
|cognition|
|response to xenobiotic stimulus|
|response to light stimulus|
|glutamatergic synapse|
|neuronal cell body|
|negative regulation of protein phosphorylation|
|response to radiation|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|response to toxic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|response to organic cyclic compound|
|regulation of transferase activity|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.37|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.92|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.89|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.84|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.08|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R1B Expression in NALM6 Cells: -0.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>