======= PPP2R1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2R1A
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 scaffold subunit Aalpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5518|5518]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30153|P30153]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2R1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2R1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605983|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). {ECO:0000269|PubMed:15525651, ECO:0000269|PubMed:16580887}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic spindle elongation|
|regulation of meiotic cell cycle process involved in oocyte maturation|
|mitotic sister chromatid separation|
|meiotic sister chromatid cohesion, centromeric|
|regulation of oocyte maturation|
|meiotic sister chromatid segregation|
|meiotic sister chromatid cohesion|
|protein antigen binding|
|centromeric sister chromatid cohesion|
|spindle elongation|
|mitotic nuclear envelope reassembly|
|meiosis II cell cycle process|
|meiosis II|
|regulation of oogenesis|
|regulation of oocyte development|
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of tyrosine phosphorylation of STAT protein|
|meiotic spindle organization|
|peptidyl-serine dephosphorylation|
|nuclear envelope reassembly|
|protein phosphatase type 2A complex|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|regulation of cell maturation|
|inactivation of MAPK activity|
|chromosome separation|
|female meiotic nuclear division|
|protein phosphatase regulator activity|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|sister chromatid cohesion|
|regulation of meiotic cell cycle|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|nuclear envelope organization|
|chromosome, centromeric region|
|lateral plasma membrane|
|protein serine/threonine phosphatase activity|
|chromosome organization involved in meiotic cell cycle|
|negative regulation of MAP kinase activity|
|regulation of tyrosine phosphorylation of STAT protein|
|ceramide metabolic process|
|meiotic chromosome segregation|
|ciliary basal body-plasma membrane docking|
|regulation of DNA replication|
|mitotic sister chromatid segregation|
|regulation of phosphoprotein phosphatase activity|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|female gamete generation|
|regulation of receptor signaling pathway via JAK-STAT|
|G2/M transition of mitotic cell cycle|
|nucleus organization|
|negative regulation of protein serine/threonine kinase activity|
|cell cycle G2/M phase transition|
|regulation of receptor signaling pathway via STAT|
|regulation of protein dephosphorylation|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule cytoskeleton|
|meiotic nuclear division|
|regulation of extrinsic apoptotic signaling pathway|
|sphingolipid metabolic process|
|spindle organization|
|regulation of reproductive process|
|meiotic cell cycle process|
|negative regulation of MAPK cascade|
|organelle localization by membrane tethering|
|positive regulation of apoptotic signaling pathway|
|regulation of phosphatase activity|
|membrane docking|
|negative regulation of cell growth|
|regulation of G2/M transition of mitotic cell cycle|
|nuclear-transcribed mRNA catabolic process|
|membrane lipid metabolic process|
|regulation of dephosphorylation|
|regulation of cell cycle G2/M phase transition|
|protein dephosphorylation|
|mRNA catabolic process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|negative regulation of protein kinase activity|
|negative regulation of growth|
|negative regulation of kinase activity|
|RNA catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|mitotic cell cycle phase transition|
|chromosome segregation|
|negative regulation of transferase activity|
|cell cycle phase transition|
|nuclear division|
|dephosphorylation|
|organelle fission|
|second-messenger-mediated signaling|
|regulation of MAP kinase activity|
|cilium assembly|
|glutamatergic synapse|
|cellular process involved in reproduction in multicellular organism|
|regulation of Wnt signaling pathway|
|cilium organization|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|endomembrane system organization|
|dendrite|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|organic cyclic compound catabolic process|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|microtubule-based process|
|regulation of cell adhesion|
|mitotic cell cycle|
|gamete generation|
|mRNA metabolic process|
|positive regulation of cell death|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|organelle assembly|
|regulation of multi-organism process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|regulation of kinase activity|
|RNA processing|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of cell development|
|cellular lipid metabolic process|
|regulation of transferase activity|
|multi-organism reproductive process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|lipid metabolic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.15|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.12|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.07|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-2.03|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.01|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.92|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.89|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.89|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.86|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.71|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.8|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.85|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.23|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.28|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.3|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.31|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.61|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.9|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|3.22|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.53|
|[[:results:exp59|UMK57 1μM R01 exp59]]|5.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lcmt1|LCMT1]]|0.721|
|[[:human genes:p:ppme1|PPME1]]|0.575|
|[[:human genes:p:ppp2r5c|PPP2R5C]]|0.516|
|[[:human genes:p:ppp2r2a|PPP2R2A]]|0.488|
|[[:human genes:p:ppp2r4|PPP2R4]]|0.461|
|[[:human genes:k:kif18b|KIF18B]]|0.439|
|[[:human genes:t:tiprl|TIPRL]]|0.439|
|[[:human genes:c:clasp2|CLASP2]]|0.425|
|[[:human genes:p:ppp2ca|PPP2CA]]|0.413|
|[[:human genes:p:ppp6r3|PPP6R3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 570/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|19/28|
|bone|21/26|
|breast|23/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|7/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|18/21|
|liver|16/20|
|lung|54/75|
|lymphocyte|11/16|
|ovary|18/26|
|pancreas|18/24|
|peripheral nervous system|15/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|24/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1736
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2R1A Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>