======= PPP2R3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP2R3C
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 regulatory subunit B''gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55012|55012]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969Q6|Q969Q6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2R3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2R3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of antimicrobial humoral response|
|positive regulation of B cell differentiation|
|regulation of mitochondrial depolarization|
|B cell homeostasis|
|regulation of B cell differentiation|
|spleen development|
|T cell homeostasis|
|regulation of membrane depolarization|
|cortical cytoskeleton organization|
|lymphocyte homeostasis|
|leukocyte homeostasis|
|regulation of mitochondrial membrane potential|
|positive regulation of lymphocyte differentiation|
|spindle|
|regulation of humoral immune response|
|positive regulation of leukocyte differentiation|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|positive regulation of hemopoiesis|
|homeostasis of number of cells|
|regulation of B cell activation|
|regulation of dephosphorylation|
|regulation of leukocyte differentiation|
|activation of protein kinase activity|
|positive regulation of lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of membrane potential|
|regulation of hemopoiesis|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|microtubule-based process|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of kinase activity|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|cytoskeleton organization|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.93|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.77|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.74|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.71|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.75|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.81|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.97|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.07|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.12|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.24|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.29|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.29|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.34|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.47|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.48|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.63|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.67|
|[[:human genes:e:eny2|ENY2]]|0.578|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.578|
|[[:human genes:d:dohh|DOHH]]|0.555|
|[[:human genes:s:srp14|SRP14]]|0.553|
|[[:human genes:a:alg1|ALG1]]|0.55|
|[[:human genes:r:rptor|RPTOR]]|0.549|
|[[:human genes:t:thg1l|THG1L]]|0.548|
|[[:human genes:p:pmm2|PMM2]]|0.545|
|[[:human genes:b:bap1|BAP1]]|0.543|
|[[:human genes:r:rnmt|RNMT]]|0.542|
|[[:human genes:a:apaf1|APAF1]]|0.533|
|[[:human genes:u:uhrf1|UHRF1]]|0.533|
|[[:human genes:c:csnk2b|CSNK2B]]|0.523|
|[[:human genes:t:triap1|TRIAP1]]|0.513|
|[[:human genes:d:dpagt1|DPAGT1]]|0.512|
|[[:human genes:g:gmppb|GMPPB]]|0.511|
|[[:human genes:g:gfpt1|GFPT1]]|0.509|
|[[:human genes:h:hspd1|HSPD1]]|0.505|
|[[:human genes:m:mtor|MTOR]]|0.504|
|[[:human genes:w:wdr24|WDR24]]|0.5|
|[[:human genes:u:ube2g2|UBE2G2]]|0.499|
|[[:human genes:p:pelo|PELO]]|0.496|
|[[:human genes:u:uap1|UAP1]]|0.495|
|[[:human genes:u:ube2k|UBE2K]]|0.493|
|[[:human genes:a:alg5|ALG5]]|0.486|
|[[:human genes:p:ppa2|PPA2]]|0.484|
|[[:human genes:p:plaa|PLAA]]|0.484|
|[[:human genes:l:lsm10|LSM10]]|0.475|
|[[:human genes:a:aars|AARS]]|0.474|
|[[:human genes:i:id3|ID3]]|0.472|
|[[:human genes:a:atxn10|ATXN10]]|0.472|
|[[:human genes:t:tsen54|TSEN54]]|0.469|
|[[:human genes:f:faf2|FAF2]]|0.468|
|[[:human genes:c:cbfb|CBFB]]|0.467|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.465|
|[[:human genes:c:casp9|CASP9]]|0.464|
|[[:human genes:n:nars|NARS]]|0.464|
|[[:human genes:a:alg6|ALG6]]|0.462|
|[[:human genes:u:ube2j1|UBE2J1]]|0.461|
|[[:human genes:b:bak1|BAK1]]|0.46|
|[[:human genes:h:hccs|HCCS]]|0.459|
|[[:human genes:r:rpe|RPE]]|0.458|
|[[:human genes:r:rpia|RPIA]]|0.458|
|[[:human genes:c:c14orf80|C14orf80]]|0.455|
|[[:human genes:h:haus8|HAUS8]]|0.454|
|[[:human genes:m:med16|MED16]]|0.45|
|[[:human genes:c:crls1|CRLS1]]|0.448|
|[[:human genes:u:uba5|UBA5]]|0.448|
|[[:human genes:d:dnajc3|DNAJC3]]|0.448|
|[[:human genes:a:alg13|ALG13]]|0.447|
|[[:human genes:c:ccdc101|CCDC101]]|0.445|
|[[:human genes:r:rtcb|RTCB]]|0.444|
|[[:human genes:u:utp23|UTP23]]|0.442|
|[[:human genes:d:dnajb11|DNAJB11]]|0.439|
|[[:human genes:e:eno1|ENO1]]|0.438|
|[[:human genes:d:dr1|DR1]]|0.437|
|[[:human genes:d:dad1|DAD1]]|0.435|
|[[:human genes:d:ddx39a|DDX39A]]|0.435|
|[[:human genes:c:cep350|CEP350]]|0.433|
|[[:human genes:s:slc25a26|SLC25A26]]|0.431|
|[[:human genes:d:ddhd2|DDHD2]]|0.43|
|[[:human genes:r:romo1|ROMO1]]|0.429|
|[[:human genes:n:nat9|NAT9]]|0.429|
|[[:human genes:t:trim28|TRIM28]]|0.429|
|[[:human genes:u:ubqln1|UBQLN1]]|0.426|
|[[:human genes:r:rpp21|RPP21]]|0.425|
|[[:human genes:d:dhrsx|DHRSX]]|0.424|
|[[:human genes:o:oraov1|ORAOV1]]|0.424|
|[[:human genes:s:ssb|SSB]]|0.424|
|[[:human genes:t:trmt10a|TRMT10A]]|0.423|
|[[:human genes:n:nsd1|NSD1]]|0.422|
|[[:human genes:a:atp5j|ATP5J]]|0.422|
|[[:human genes:t:tle4|TLE4]]|0.421|
|[[:human genes:w:wdr1|WDR1]]|0.42|
|[[:human genes:t:trmt5|TRMT5]]|0.419|
|[[:human genes:d:diablo|DIABLO]]|0.418|
|[[:human genes:n:nae1|NAE1]]|0.417|
|[[:human genes:t:tti2|TTI2]]|0.416|
|[[:human genes:v:vhl|VHL]]|0.416|
|[[:human genes:a:adsl|ADSL]]|0.416|
|[[:human genes:d:dhps|DHPS]]|0.416|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.415|
|[[:human genes:p:pam16|PAM16]]|0.415|
|[[:human genes:o:osgep|OSGEP]]|0.415|
|[[:human genes:o:opa1|OPA1]]|0.414|
|[[:human genes:t:ten1|TEN1]]|0.414|
|[[:human genes:k:kctd5|KCTD5]]|0.414|
|[[:human genes:e:eprs|EPRS]]|0.413|
|[[:human genes:t:txnrd1|TXNRD1]]|0.412|
|[[:human genes:m:meaf6|MEAF6]]|0.412|
|[[:human genes:p:ppp6c|PPP6C]]|0.412|
|[[:human genes:t:tmed10|TMED10]]|0.411|
|[[:human genes:d:ddost|DDOST]]|0.409|
|[[:human genes:s:slc35b1|SLC35B1]]|0.409|
|[[:human genes:v:vezt|VEZT]]|0.407|
|[[:human genes:t:taz|TAZ]]|0.406|
|[[:human genes:p:pkm|PKM]]|0.406|
|[[:human genes:t:tmem41b|TMEM41B]]|0.406|
|[[:human genes:p:pdap1|PDAP1]]|0.405|
|[[:human genes:s:sdha|SDHA]]|0.404|
|[[:human genes:p:phb|PHB]]|0.404|
|[[:human genes:t:tbca|TBCA]]|0.401|
|[[:human genes:d:dpf2|DPF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 173/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|11/28|
|bone|2/26|
|breast|10/33|
|central nervous system|5/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|11/21|
|liver|5/20|
|lung|15/75|
|lymphocyte|3/16|
|ovary|6/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1285
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2R3C Expression in NALM6 Cells: 5.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>