======= PPP2R4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTPA
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 2 phosphatase activator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5524|5524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15257|Q15257]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP2R4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP2R4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600756|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTPA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tyrosine phosphatase activator activity|
|protein phosphatase type 2A complex|
|positive regulation of phosphoprotein phosphatase activity|
|calcium channel complex|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|positive regulation of phosphatase activity|
|positive regulation of protein dephosphorylation|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|positive regulation of dephosphorylation|
|peptidyl-proline modification|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|mitotic spindle organization|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|spindle organization|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|ATPase activity|
|signaling receptor binding|
|negative regulation of hydrolase activity|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|microtubule-based process|
|mitotic cell cycle|
|positive regulation of cell death|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|cell cycle|
|positive regulation of catalytic activity|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.88|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.78|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.83|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.9|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.02|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.3|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.95|
|[[:results:exp59|UMK57 1μM R01 exp59]]|3.37|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|4.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tiprl|TIPRL]]|0.682|
|[[:human genes:l:lcmt1|LCMT1]]|0.595|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.584|
|[[:human genes:p:ppme1|PPME1]]|0.583|
|[[:human genes:p:ppp6c|PPP6C]]|0.523|
|[[:human genes:p:ppp6r3|PPP6R3]]|0.464|
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.461|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 336/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|9/28|
|bone|11/26|
|breast|11/33|
|central nervous system|19/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|5/21|
|liver|8/20|
|lung|32/75|
|lymphocyte|6/16|
|ovary|11/26|
|pancreas|15/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|11/22|
|urinary tract|15/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1221
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP2R4 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>