======= PRDX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX2
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7001|7001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32119|P32119]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000269|PubMed:9497357}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Redoxin|
|1-cysPrx C|
|AhpC-TSA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory burst involved in inflammatory response|
|thioredoxin peroxidase activity|
|respiratory burst involved in defense response|
|removal of superoxide radicals|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|cellular response to oxygen radical|
|cellular response to superoxide|
|production of molecular mediator involved in inflammatory response|
|response to superoxide|
|response to oxygen radical|
|antioxidant activity|
|respiratory burst|
|regulation of hydrogen peroxide metabolic process|
|regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|hydrogen peroxide catabolic process|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of signal transduction in absence of ligand|
|regulation of cofactor metabolic process|
|hydrogen peroxide metabolic process|
|T cell proliferation|
|superoxide metabolic process|
|negative regulation of T cell differentiation|
|thymus development|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|negative regulation of lymphocyte differentiation|
|antibiotic catabolic process|
|positive regulation of wound healing|
|cofactor catabolic process|
|positive regulation of response to wounding|
|cell redox homeostasis|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of NF-kappaB transcription factor activity|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cellular oxidant detoxification|
|negative regulation of response to biotic stimulus|
|leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|cellular detoxification|
|negative regulation of extrinsic apoptotic signaling pathway|
|antibiotic metabolic process|
|negative regulation of T cell activation|
|reactive oxygen species metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|detoxification|
|cellular response to reactive oxygen species|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of wound healing|
|negative regulation of lymphocyte activation|
|drug catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|negative regulation of DNA-binding transcription factor activity|
|regulation of response to wounding|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of reactive oxygen species metabolic process|
|response to reactive oxygen species|
|negative regulation of cell activation|
|homeostasis of number of cells|
|cellular response to toxic substance|
|negative regulation of multi-organism process|
|negative regulation of apoptotic signaling pathway|
|T cell activation|
|cellular response to oxidative stress|
|positive regulation of MAP kinase activity|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|gland development|
|regulation of DNA-binding transcription factor activity|
|cofactor metabolic process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of body fluid levels|
|inflammatory response|
|drug metabolic process|
|response to toxic substance|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of MAPK cascade|
|cell population proliferation|
|positive regulation of kinase activity|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|response to bacterium|
|negative regulation of cell differentiation|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|leukocyte activation|
|negative regulation of developmental process|
|oxidation-reduction process|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.77|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7856
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX2 Expression in NALM6 Cells: 0.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>