======= PREPL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PREPL
  * **<color #00a2e8>Official Name</color>**: prolyl endopeptidase like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9581|9581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4J6C6|Q4J6C6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PREPL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PREPL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase S9|
|Peptidase S9 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine-type exopeptidase activity|
|Golgi to plasma membrane protein transport|
|establishment of protein localization to plasma membrane|
|Golgi to plasma membrane transport|
|regulation of synaptic vesicle exocytosis|
|peptidase activity|
|vesicle-mediated transport to the plasma membrane|
|retrograde transport, endosome to Golgi|
|post-Golgi vesicle-mediated transport|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of neurotransmitter transport|
|cytosolic transport|
|regulation of regulated secretory pathway|
|serine-type endopeptidase activity|
|trans-Golgi network|
|protein localization to plasma membrane|
|regulation of exocytosis|
|protein localization to cell periphery|
|endosomal transport|
|establishment of protein localization to membrane|
|regulation of neurotransmitter levels|
|cytoskeleton|
|Golgi vesicle transport|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|protein localization to membrane|
|regulation of vesicle-mediated transport|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|Golgi apparatus|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.96|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.7|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.71|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.77|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.78|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.86|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.92|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.97|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.01|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.03|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.07|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.07|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.11|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.18|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.21|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.27|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.33|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.38|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.4|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.49|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.52|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fastkd2|FASTKD2]]|0.544|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.542|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.533|
|[[:human genes:r:rmnd1|RMND1]]|0.527|
|[[:human genes:p:pde12|PDE12]]|0.524|
|[[:human genes:e:eral1|ERAL1]]|0.519|
|[[:human genes:a:acad9|ACAD9]]|0.518|
|[[:human genes:p:pet117|PET117]]|0.518|
|[[:human genes:n:nsun4|NSUN4]]|0.511|
|[[:human genes:g:grsf1|GRSF1]]|0.502|
|[[:human genes:f:ftsj2|FTSJ2]]|0.492|
|[[:human genes:n:ndufs5|NDUFS5]]|0.483|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.482|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.478|
|[[:human genes:r:rexo2|REXO2]]|0.474|
|[[:human genes:m:mcur1|MCUR1]]|0.472|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.469|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.464|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.463|
|[[:human genes:n:ndufv2|NDUFV2]]|0.457|
|[[:human genes:n:ndufs2|NDUFS2]]|0.456|
|[[:human genes:m:mto1|MTO1]]|0.455|
|[[:human genes:d:ddx28|DDX28]]|0.455|
|[[:human genes:n:ndufb10|NDUFB10]]|0.452|
|[[:human genes:m:malsu1|MALSU1]]|0.449|
|[[:human genes:s:ssbp1|SSBP1]]|0.446|
|[[:human genes:t:trit1|TRIT1]]|0.445|
|[[:human genes:m:mrpl49|MRPL49]]|0.445|
|[[:human genes:c:cox6a1|COX6A1]]|0.444|
|[[:human genes:m:mettl17|METTL17]]|0.444|
|[[:human genes:n:nubpl|NUBPL]]|0.438|
|[[:human genes:t:tfb1m|TFB1M]]|0.438|
|[[:human genes:c:cars2|CARS2]]|0.436|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.434|
|[[:human genes:t:tsfm|TSFM]]|0.434|
|[[:human genes:c:clpp|CLPP]]|0.43|
|[[:human genes:m:mtif2|MTIF2]]|0.428|
|[[:human genes:i:ict1|ICT1]]|0.425|
|[[:human genes:p:pet112|PET112]]|0.423|
|[[:human genes:m:mrpl22|MRPL22]]|0.421|
|[[:human genes:m:mrps22|MRPS22]]|0.416|
|[[:human genes:m:mcat|MCAT]]|0.415|
|[[:human genes:s:sfxn4|SFXN4]]|0.414|
|[[:human genes:p:ptcd3|PTCD3]]|0.414|
|[[:human genes:n:ndufb4|NDUFB4]]|0.414|
|[[:human genes:n:ndufb9|NDUFB9]]|0.414|
|[[:human genes:s:slc30a9|SLC30A9]]|0.413|
|[[:human genes:n:ndufa8|NDUFA8]]|0.413|
|[[:human genes:m:mrps18b|MRPS18B]]|0.412|
|[[:human genes:r:rpusd3|RPUSD3]]|0.411|
|[[:human genes:c:cluh|CLUH]]|0.411|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.41|
|[[:human genes:c:c1qbp|C1QBP]]|0.41|
|[[:human genes:m:mrpl28|MRPL28]]|0.407|
|[[:human genes:n:nars2|NARS2]]|0.403|
|[[:human genes:q:qrsl1|QRSL1]]|0.4|
|[[:human genes:n:ndufc1|NDUFC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1795
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PREPL Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>