======= PRKCE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKCE
  * **<color #00a2e8>Official Name</color>**: protein kinase C epsilon
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5581|5581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02156|Q02156]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKCE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKCE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F- actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL- mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. {ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:15355962, ECO:0000269|PubMed:16757566, ECO:0000269|PubMed:17603037, ECO:0000269|PubMed:17875639, ECO:0000269|PubMed:17875724}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|Pkinase Tyr|
|Pkinase C|
|C2|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cellular glucuronidation|
|regulation of cellular glucuronidation|
|signaling receptor activator activity|
|calcium-independent protein kinase C activity|
|ethanol binding|
|TRAM-dependent toll-like receptor 4 signaling pathway|
|TRAM-dependent toll-like receptor signaling pathway|
|positive regulation of mucus secretion|
|regulation of mucus secretion|
|positive regulation of fibroblast migration|
|negative regulation of sodium ion transmembrane transporter activity|
|positive regulation of synaptic transmission, GABAergic|
|negative regulation of sodium ion transmembrane transport|
|macrophage activation involved in immune response|
|locomotory exploration behavior|
|cellular response to ethanol|
|protein kinase C activity|
|cellular response to prostaglandin E stimulus|
|negative regulation of sodium ion transport|
|toll-like receptor 4 signaling pathway|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|positive regulation of lipid catabolic process|
|exploration behavior|
|actin monomer binding|
|14-3-3 protein binding|
|regulation of fibroblast migration|
|response to prostaglandin|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of synaptic transmission, GABAergic|
|response to isoquinoline alkaloid|
|response to morphine|
|lipopolysaccharide-mediated signaling pathway|
|cell periphery|
|positive regulation of cytokinesis|
|enzyme activator activity|
|macrophage activation|
|regulation of sodium ion transmembrane transporter activity|
|regulation of lipid catabolic process|
|positive regulation of wound healing|
|positive regulation of protein localization to plasma membrane|
|cellular response to fatty acid|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of protein localization to cell periphery|
|regulation of sodium ion transmembrane transport|
|positive regulation of response to wounding|
|negative regulation of ion transmembrane transporter activity|
|positive regulation of insulin secretion|
|negative regulation of protein ubiquitination|
|response to anesthetic|
|regulation of release of sequestered calcium ion into cytosol|
|positive regulation of carbohydrate metabolic process|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|negative regulation of protein modification by small protein conjugation or removal|
|response to fatty acid|
|cellular response to alcohol|
|regulation of sodium ion transport|
|positive regulation of cell division|
|regulation of cytokinesis|
|positive regulation of actin filament polymerization|
|cellular response to ketone|
|regulation of protein localization to plasma membrane|
|negative regulation of ion transmembrane transport|
|positive regulation of peptide hormone secretion|
|toll-like receptor signaling pathway|
|regulation of calcium ion transport into cytosol|
|response to alkaloid|
|regulation of protein localization to cell periphery|
|negative regulation of transmembrane transport|
|cellular response to antibiotic|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein localization to membrane|
|regulation of sequestering of calcium ion|
|response to ethanol|
|pattern recognition receptor signaling pathway|
|positive regulation of hormone secretion|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|regulation of wound healing|
|platelet activation|
|Fc receptor mediated stimulatory signaling pathway|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|Fc-gamma receptor signaling pathway|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|positive regulation of synaptic transmission|
|regulation of actin filament polymerization|
|regulation of response to wounding|
|regulation of cell division|
|regulation of cellular ketone metabolic process|
|peptidyl-serine phosphorylation|
|regulation of insulin secretion|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|response to ammonium ion|
|cellular response to hypoxia|
|regulation of protein localization to membrane|
|cellular response to molecule of bacterial origin|
|response to ketone|
|locomotory behavior|
|positive regulation of supramolecular fiber organization|
|cellular response to decreased oxygen levels|
|peptidyl-serine modification|
|regulation of protein ubiquitination|
|regulation of carbohydrate metabolic process|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|regulation of cell-substrate adhesion|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|cellular response to biotic stimulus|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|regulation of protein modification by small protein conjugation or removal|
|response to alcohol|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|Fc receptor signaling pathway|
|regulation of calcium ion transport|
|positive regulation of protein complex assembly|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of ion transmembrane transporter activity|
|activation of innate immune response|
|regulation of actin filament organization|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of transporter activity|
|positive regulation of cell cycle process|
|positive regulation of peptide secretion|
|blood coagulation|
|coagulation|
|hemostasis|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|phagocytosis|
|regulation of cation transmembrane transport|
|positive regulation of innate immune response|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|response to acid chemical|
|enzyme binding|
|regulation of supramolecular fiber organization|
|response to decreased oxygen levels|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|cytoskeleton|
|positive regulation of cell cycle|
|regulation of cellular component size|
|response to oxygen levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of lipid metabolic process|
|cellular response to drug|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|cell division|
|regulation of peptide secretion|
|regulation of body fluid levels|
|positive regulation of cell migration|
|response to toxic substance|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|response to wounding|
|behavior|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell adhesion|
|response to bacterium|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.34|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.21|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.04|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.97|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.79|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.77|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.7|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nras|NRAS]]|0.544|
|[[:human genes:s:shoc2|SHOC2]]|0.492|
|[[:human genes:b:braf|BRAF]]|0.486|
|[[:human genes:b:bcl2|BCL2]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4510
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKCE Expression in NALM6 Cells: 5.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>