======= PRLH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRLH
  * **<color #00a2e8>Official Name</color>**: prolactin releasing hormone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51052|51052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P81277|P81277]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRLH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRLH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602663|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prolactin-releasing peptide receptor binding|
|reduction of food intake in response to dietary excess|
|response to dietary excess|
|neuropeptide hormone activity|
|eating behavior|
|autonomic nervous system development|
|energy reserve metabolic process|
|regulation of multicellular organism growth|
|feeding behavior|
|hormone activity|
|fat cell differentiation|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|tissue homeostasis|
|response to insulin|
|energy derivation by oxidation of organic compounds|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|anatomical structure homeostasis|
|response to peptide hormone|
|generation of precursor metabolites and energy|
|response to peptide|
|response to nutrient levels|
|response to extracellular stimulus|
|behavior|
|regulation of growth|
|response to hormone|
|oxidation-reduction process|
|response to organonitrogen compound|
|response to nitrogen compound|
|lipid metabolic process|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.482|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRLH Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>