======= PRRT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRRT2
  * **<color #00a2e8>Official Name</color>**: proline rich transmembrane protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112476|112476]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6L0|Q7Z6L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRRT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRRT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD225|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of short-term synaptic potentiation|
|negative regulation of short-term synaptic potentiation|
|negative regulation of SNARE complex assembly|
|negative regulation of vesicle fusion|
|regulation of SNARE complex assembly|
|synaptic vesicle fusion to presynaptic active zone membrane|
|vesicle fusion to plasma membrane|
|neuromuscular process controlling posture|
|syntaxin-1 binding|
|regulation of vesicle fusion|
|axon terminus|
|synaptic vesicle exocytosis|
|synaptic vesicle membrane|
|exocytic process|
|vesicle fusion|
|presynaptic membrane|
|organelle membrane fusion|
|presynapse|
|organelle fusion|
|signal release from synapse|
|neurotransmitter secretion|
|neuromuscular process|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|negative regulation of protein complex assembly|
|vesicle|
|dendritic spine|
|signal release|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|postsynaptic density|
|vesicle organization|
|regulation of neurotransmitter levels|
|negative regulation of organelle organization|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|synaptic signaling|
|negative regulation of transport|
|cell junction|
|regulation of vesicle-mediated transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|exocytosis|
|membrane organization|
|regulation of cellular component biogenesis|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|regulation of organelle organization|
|nervous system process|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.95|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16991
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRRT2 Expression in NALM6 Cells: -0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>