======= PSEN1 =======
== Gene Information ==
* **Official Symbol**: PSEN1
* **Official Name**: presenilin 1
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5663|5663]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P49768|P49768]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=PSEN1&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSEN1|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/104311|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
* **UniProt Summary**: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15274632, PubMed:10545183, PubMed:10593990, PubMed:10206644, PubMed:10899933, PubMed:10811883, PubMed:12679784, PubMed:12740439, PubMed:25043039, PubMed:26280335). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:9738936, PubMed:10593990, PubMed:10899933, PubMed:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:9738936, PubMed:11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). {ECO:0000250|UniProtKB:P49769, ECO:0000269|PubMed:10206644, ECO:0000269|PubMed:10545183, ECO:0000269|PubMed:10593990, ECO:0000269|PubMed:10811883, ECO:0000269|PubMed:10899933, ECO:0000269|PubMed:11953314, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12740439, ECO:0000269|PubMed:15274632, ECO:0000269|PubMed:15341515, ECO:0000269|PubMed:16305624, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:9738936}.
|Presenilin|
|Cajal-Retzius cell differentiation|
|negative regulation of core promoter binding|
|smooth endoplasmic reticulum calcium ion homeostasis|
|positive regulation of L-glutamate import across plasma membrane|
|negative regulation of low-density lipoprotein receptor activity|
|astrocyte activation involved in immune response|
|positive regulation of amyloid fibril formation|
|synaptic vesicle targeting|
|regulation of L-glutamate import across plasma membrane|
|positive regulation of neurotransmitter uptake|
|Notch receptor processing, ligand-dependent|
|gamma-secretase complex|
|amyloid-beta formation|
|aspartic endopeptidase activity, intramembrane cleaving|
|choline transport|
|regulation of resting membrane potential|
|regulation of amyloid fibril formation|
|regulation of amino acid transmembrane transport|
|positive regulation of anion transmembrane transport|
|regulation of core promoter binding|
|regulation of amino acid import across plasma membrane|
|modulation of age-related behavioral decline|
|skin morphogenesis|
|ciliary rootlet|
|neuron projection maintenance|
|Notch receptor processing|
|amyloid precursor protein catabolic process|
|negative regulation of epidermal growth factor-activated receptor activity|
|positive regulation of receptor recycling|
|negative regulation of ubiquitin-protein transferase activity|
|dorsal/ventral neural tube patterning|
|amyloid precursor protein metabolic process|
|myeloid dendritic cell differentiation|
|positive regulation of amino acid transport|
|astrocyte activation|
|membrane protein intracellular domain proteolysis|
|regulation of neurotransmitter uptake|
|amyloid-beta metabolic process|
|positive regulation of tumor necrosis factor biosynthetic process|
|negative regulation of transcription regulatory region DNA binding|
|aspartic-type endopeptidase activity|
|myeloid dendritic cell activation|
|endoplasmic reticulum calcium ion homeostasis|
|positive regulation of glycolytic process|
|membrane protein ectodomain proteolysis|
|regulation of receptor recycling|
|cerebral cortex neuron differentiation|
|nuclear outer membrane|
|positive regulation of coagulation|
|smooth endoplasmic reticulum|
|regulation of anion transmembrane transport|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|regulation of tumor necrosis factor biosynthetic process|
|positive regulation of response to drug|
|regulation of amino acid transport|
|organic cation transport|
|dendritic cell differentiation|
|brain morphogenesis|
|neural tube patterning|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|astrocyte development|
|dendritic shaft|
|membrane protein proteolysis|
|positive regulation of protein import into nucleus|
|glial cell activation|
|positive regulation of neurotransmitter transport|
|positive regulation of protein import|
|cellular response to amyloid-beta|
|neuron projection organization|
|neuroinflammatory response|
|aggresome|
|positive regulation of dendritic spine development|
|cerebral cortex cell migration|
|neuron apoptotic process|
|negative regulation of endocytosis|
|thymus development|
|positive regulation of nucleotide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of ubiquitin-dependent protein catabolic process|
|response to amyloid-beta|
|positive regulation of anion transport|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|regulation of ubiquitin-protein transferase activity|
|neuron death|
|regulation of transcription regulatory region DNA binding|
|ammonium transport|
|calcium channel activity|
|activation of MAPKK activity|
|astrocyte differentiation|
|negative regulation of DNA binding|
|regulation of protein import into nucleus|
|neural retina development|
|integral component of presynaptic membrane|
|negative regulation of signaling receptor activity|
|regulation of protein import|
|regulation of organic acid transport|
|telencephalon cell migration|
|azurophil granule membrane|
|heart looping|
|rough endoplasmic reticulum|
|forebrain cell migration|
|autophagosome assembly|
|positive regulation of nucleocytoplasmic transport|
|synaptic vesicle exocytosis|
|T cell activation involved in immune response|
|autophagosome organization|
|somitogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|positive regulation of cytokine biosynthetic process|
|exocytic process|
|negative regulation of axonogenesis|
|regulation of synaptic transmission, glutamatergic|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|negative regulation of protein ubiquitination|
|positive regulation of protein localization to nucleus|
|embryonic heart tube development|
|endopeptidase activity|
|neuromuscular junction|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|dorsal/ventral pattern formation|
|regulation of coagulation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|somite development|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of epidermal growth factor receptor signaling pathway|
|beta-catenin binding|
|kinetochore|
|positive regulation of tumor necrosis factor production|
|ephrin receptor signaling pathway|
|hematopoietic progenitor cell differentiation|
|epithelial cell proliferation|
|negative regulation of cellular protein catabolic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|cell fate specification|
|PDZ domain binding|
|regulation of carbohydrate catabolic process|
|regulation of protein tyrosine kinase activity|
|post-embryonic development|
|vesicle targeting|
|regulation of ERBB signaling pathway|
|regulation of amine transport|
|positive regulation of protein binding|
|regulation of anion transport|
|segmentation|
|positive regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of response to drug|
|sarcolemma|
|signal release from synapse|
|neurotransmitter secretion|
|cerebellum development|
|positive regulation of proteasomal protein catabolic process|
|regulation of cytokine biosynthetic process|
|regulation of nucleocytoplasmic transport|
|glial cell development|
|lymphocyte activation involved in immune response|
|metencephalon development|
|myeloid leukocyte differentiation|
|regulation of protein localization to nucleus|
|regulation of purine nucleotide metabolic process|
|cerebral cortex development|
|memory|
|determination of left/right symmetry|
|synaptic vesicle cycle|
|regulation of nucleotide metabolic process|
|neuron migration|
|synaptic vesicle|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of ATP metabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|determination of bilateral symmetry|
|specification of symmetry|
|embryonic limb morphogenesis|
|regulation of DNA binding|
|embryonic appendage morphogenesis|
|Notch signaling pathway|
|growth cone|
|vesicle-mediated transport in synapse|
|vacuole organization|
|negative regulation of protein catabolic process|
|cell cortex|
|positive regulation of small molecule metabolic process|
|retina development in camera-type eye|
|positive regulation of cellular protein catabolic process|
|regulation of neurotransmitter transport|
|negative regulation of neuron apoptotic process|
|regulation of tumor necrosis factor production|
|regulation of dendrite development|
|limb morphogenesis|
|appendage morphogenesis|
|hindbrain development|
|early endosome membrane|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|negative regulation of neuron projection development|
|positive regulation of ion transmembrane transport|
|protein processing|
|regulation of generation of precursor metabolites and energy|
|neural tube development|
|macroautophagy|
|signal release|
|glial cell differentiation|
|negative regulation of binding|
|regulation of signaling receptor activity|
|pallium development|
|establishment of vesicle localization|
|T cell receptor signaling pathway|
|positive regulation of binding|
|central nervous system neuron differentiation|
|neurotransmitter transport|
|limb development|
|appendage development|
|negative regulation of cell projection organization|
|regulation of proteasomal protein catabolic process|
|vesicle localization|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|positive regulation of supramolecular fiber organization|
|calcium ion transmembrane transport|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|regulation of carbohydrate metabolic process|
|regulation of endocytosis|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of intracellular transport|
|gliogenesis|
|mitochondrial transport|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|anterior/posterior pattern specification|
|regulation of protein binding|
|myeloid cell differentiation|
|protein maturation|
|negative regulation of apoptotic signaling pathway|
|negative regulation of protein kinase activity|
|membrane raft|
|negative regulation of neuron differentiation|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|T cell activation|
|skeletal system morphogenesis|
|nuclear membrane|
|negative regulation of kinase activity|
|cell fate commitment|
|regulation of cellular protein catabolic process|
|calcium ion transport|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cellular catabolic process|
|macromolecule glycosylation|
|telencephalon development|
|protein glycosylation|
|learning or memory|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of MAP kinase activity|
|glycosylation|
|synapse organization|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|aging|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|cadherin binding|
|regulation of neuron death|
|negative regulation of nervous system development|
|camera-type eye development|
|neuron projection|
|glycoprotein biosynthetic process|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|activation of protein kinase activity|
|leukocyte differentiation|
|regionalization|
|negative regulation of cell development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|eye development|
|regulation of Wnt signaling pathway|
|visual system development|
|establishment of organelle localization|
|positive regulation of cellular catabolic process|
|sensory system development|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of binding|
|positive regulation of cell projection organization|
|skin development|
|lymphocyte activation|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|forebrain development|
|response to oxidative stress|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|gland development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|response to peptide|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|neutrophil degranulation|
|blood vessel development|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|centrosome|
|neutrophil activation involved in immune response|
|skeletal system development|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|heart development|
|peptide metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell junction|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|hemopoiesis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|positive regulation of kinase activity|
|organelle localization|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|cell surface|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|chordate embryonic development|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|organelle assembly|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|head development|
|ion homeostasis|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cation transport|
|regulation of cellular catabolic process|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|Golgi apparatus|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|immune effector process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|locomotion|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.8|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.74|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.72|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.01|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 3312
* **Expression level (log2 read counts)**: 5.86
{{:chemogenomics:nalm6 dist.png?nolink |}}