======= PSMD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMD7
  * **<color #00a2e8>Official Name</color>**: proteasome 26S subunit, non-ATPase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5713|5713]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51665|P51665]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. {ECO:0000269|PubMed:1317798}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mov34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome regulatory particle|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|secretory granule lumen|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|ficolin-1-rich granule lumen|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|positive regulation of Wnt signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|antigen processing and presentation|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|activation of innate immune response|
|regulation of animal organ morphogenesis|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|MAPK cascade|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of mitotic cell cycle|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulated exocytosis|
|regulation of cell cycle process|
|regulation of defense response|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|exocytosis|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|leukocyte activation|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.3|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.21|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.16|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.95|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.91|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.81|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.78|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.7|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.72|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.72|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.74|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.75|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.79|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.81|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.82|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.84|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.85|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.88|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.9|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.91|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.91|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.97|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.01|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.02|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.14|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.14|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.16|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.23|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.24|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.32|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.48|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.63|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|3.05|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdca3|CDCA3]]|0.519|
|[[:human genes:p:pole|POLE]]|0.5|
|[[:human genes:c:ccna2|CCNA2]]|0.488|
|[[:human genes:p:psmd3|PSMD3]]|0.487|
|[[:human genes:t:tfip11|TFIP11]]|0.485|
|[[:human genes:i:ik|IK]]|0.484|
|[[:human genes:p:psmb4|PSMB4]]|0.481|
|[[:human genes:v:vasn|VASN]]|0.479|
|[[:human genes:t:tceb3c|TCEB3C]]|0.476|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.473|
|[[:human genes:p:psmc2|PSMC2]]|0.469|
|[[:human genes:p:psmd13|PSMD13]]|0.467|
|[[:human genes:c:cope|COPE]]|0.466|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.465|
|[[:human genes:r:rad51|RAD51]]|0.463|
|[[:human genes:p:polr2j3|POLR2J3]]|0.463|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.462|
|[[:human genes:m:myo1h|MYO1H]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.46|
|[[:human genes:g:gar1|GAR1]]|0.459|
|[[:human genes:p:psma6|PSMA6]]|0.459|
|[[:human genes:p:psmd11|PSMD11]]|0.459|
|[[:human genes:p:psmb1|PSMB1]]|0.456|
|[[:human genes:t:timeless|TIMELESS]]|0.455|
|[[:human genes:t:terf2|TERF2]]|0.455|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.454|
|[[:human genes:p:psmd1|PSMD1]]|0.454|
|[[:human genes:o:ogfr|OGFR]]|0.453|
|[[:human genes:l:lrr1|LRR1]]|0.453|
|[[:human genes:t:ticrr|TICRR]]|0.452|
|[[:human genes:c:chaf1a|CHAF1A]]|0.452|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.451|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.451|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.451|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.451|
|[[:human genes:c:copg1|COPG1]]|0.449|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.447|
|[[:human genes:d:ddtl|DDTL]]|0.446|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.445|
|[[:human genes:o:orc1|ORC1]]|0.445|
|[[:human genes:p:paf1|PAF1]]|0.444|
|[[:human genes:p:pan2|PAN2]]|0.443|
|[[:human genes:r:rbm8a|RBM8A]]|0.442|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.442|
|[[:human genes:d:dnm2|DNM2]]|0.442|
|[[:human genes:r:rrn3|RRN3]]|0.441|
|[[:human genes:a:arcn1|ARCN1]]|0.44|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.439|
|[[:human genes:s:ssh2|SSH2]]|0.439|
|[[:human genes:n:napa|NAPA]]|0.439|
|[[:human genes:k:kctd17|KCTD17]]|0.436|
|[[:human genes:z:zfand5|ZFAND5]]|0.435|
|[[:human genes:s:sfpq|SFPQ]]|0.434|
|[[:human genes:c:chd4|CHD4]]|0.434|
|[[:human genes:p:psmb3|PSMB3]]|0.433|
|[[:human genes:t:tyms|TYMS]]|0.433|
|[[:human genes:c:cdc73|CDC73]]|0.431|
|[[:human genes:g:golga8o|GOLGA8O]]|0.43|
|[[:human genes:p:psmb2|PSMB2]]|0.43|
|[[:human genes:p:pold1|POLD1]]|0.429|
|[[:human genes:c:c14orf93|C14orf93]]|0.429|
|[[:human genes:m:mt1e|MT1E]]|0.429|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.428|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.428|
|[[:human genes:r:rrp7a|RRP7A]]|0.428|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.427|
|[[:human genes:w:wdr75|WDR75]]|0.425|
|[[:human genes:p:polr2d|POLR2D]]|0.425|
|[[:human genes:n:npipb5|NPIPB5]]|0.424|
|[[:human genes:s:smg1|SMG1]]|0.424|
|[[:human genes:n:nol10|NOL10]]|0.423|
|[[:human genes:s:sf3a3|SF3A3]]|0.421|
|[[:human genes:d:dtl|DTL]]|0.42|
|[[:human genes:r:ranbp2|RANBP2]]|0.42|
|[[:human genes:h:hivep3|HIVEP3]]|0.42|
|[[:human genes:k:kif3c|KIF3C]]|0.419|
|[[:human genes:a:ahctf1|AHCTF1]]|0.419|
|[[:human genes:s:supt6h|SUPT6H]]|0.419|
|[[:human genes:c:cbwd5|CBWD5]]|0.419|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.419|
|[[:human genes:n:narfl|NARFL]]|0.418|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:g:gid4|GID4]]|0.418|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.418|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.418|
|[[:human genes:s:smg7|SMG7]]|0.418|
|[[:human genes:n:nupl1|NUPL1]]|0.417|
|[[:human genes:r:rpl37a|RPL37A]]|0.417|
|[[:human genes:w:wdr43|WDR43]]|0.417|
|[[:human genes:p:psmc6|PSMC6]]|0.416|
|[[:human genes:a:aqr|AQR]]|0.415|
|[[:human genes:e:exosc9|EXOSC9]]|0.414|
|[[:human genes:c:ctage4|CTAGE4]]|0.414|
|[[:human genes:n:nup133|NUP133]]|0.413|
|[[:human genes:v:vps28|VPS28]]|0.411|
|[[:human genes:n:nup153|NUP153]]|0.411|
|[[:human genes:c:copa|COPA]]|0.411|
|[[:human genes:t:tpx2|TPX2]]|0.41|
|[[:human genes:i:igfn1|IGFN1]]|0.407|
|[[:human genes:r:riok1|RIOK1]]|0.407|
|[[:human genes:p:polr2a|POLR2A]]|0.407|
|[[:human genes:t:top1mt|TOP1MT]]|0.406|
|[[:human genes:r:rrm2|RRM2]]|0.405|
|[[:human genes:u:upf1|UPF1]]|0.404|
|[[:human genes:m:med14|MED14]]|0.403|
|[[:human genes:m:mdm2|MDM2]]|0.403|
|[[:human genes:r:rfxank|RFXANK]]|0.403|
|[[:human genes:d:dusp14|DUSP14]]|0.403|
|[[:human genes:s:sf3a1|SF3A1]]|0.403|
|[[:human genes:z:znf106|ZNF106]]|0.403|
|[[:human genes:p:psmc5|PSMC5]]|0.403|
|[[:human genes:s:supt5h|SUPT5H]]|0.402|
|[[:human genes:c:chmp4b|CHMP4B]]|0.402|
|[[:human genes:m:med17|MED17]]|0.401|
|[[:human genes:c:cdc45|CDC45]]|0.401|
|[[:human genes:t:traip|TRAIP]]|0.401|
|[[:human genes:p:psmc1|PSMC1]]|0.401|
|[[:human genes:c:cdc6|CDC6]]|0.4|
|[[:human genes:u:ubap1|UBAP1]]|0.4|
|[[:human genes:a:acsf2|ACSF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMD7 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>