======= PSME3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSME3
  * **<color #00a2e8>Official Name</color>**: proteasome activator subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10197|10197]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61289|P61289]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSME3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSME3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605129|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). {ECO:0000269|PubMed:10835274, ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824, ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PA28 beta|
|PA28 alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome activator complex|
|endopeptidase activator activity|
|MDM2/MDM4 family protein binding|
|proteasome complex|
|regulation of cellular amino acid metabolic process|
|p53 binding|
|regulation of hematopoietic stem cell differentiation|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of cellular amine metabolic process|
|NIK/NF-kappaB signaling|
|anaphase-promoting complex-dependent catabolic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of G2/M transition of mitotic cell cycle|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|interleukin-1-mediated signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of cell cycle G2/M phase transition|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of establishment of planar polarity|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of stem cell differentiation|
|tumor necrosis factor-mediated signaling pathway|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of cell cycle G1/S phase transition|
|regulation of cellular ketone metabolic process|
|positive regulation of endopeptidase activity|
|Fc-epsilon receptor signaling pathway|
|negative regulation of canonical Wnt signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|positive regulation of Wnt signaling pathway|
|regulation of mRNA stability|
|regulation of morphogenesis of an epithelium|
|antigen processing and presentation of exogenous antigen|
|regulation of proteasomal protein catabolic process|
|regulation of RNA stability|
|cellular response to hypoxia|
|antigen processing and presentation of peptide antigen|
|positive regulation of peptidase activity|
|regulation of G2/M transition of mitotic cell cycle|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|negative regulation of Wnt signaling pathway|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|cellular response to oxygen levels|
|regulation of proteolysis involved in cellular protein catabolic process|
|antigen processing and presentation|
|negative regulation of apoptotic signaling pathway|
|negative regulation of cell cycle phase transition|
|innate immune response-activating signal transduction|
|cellular response to tumor necrosis factor|
|Fc receptor signaling pathway|
|regulation of cellular protein catabolic process|
|regulation of animal organ morphogenesis|
|activation of innate immune response|
|response to tumor necrosis factor|
|regulation of canonical Wnt signaling pathway|
|protein deubiquitination|
|antigen receptor-mediated signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|positive regulation of innate immune response|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|regulation of mitotic cell cycle|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|regulation of cell cycle process|
|regulation of defense response|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-3.34|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.06|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.68|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.56|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.48|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.47|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.4|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.3|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.29|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.29|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.14|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.03|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.98|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.97|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.83|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.77|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.74|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.71|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.7|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.75|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.82|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.82|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.86|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.98|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.05|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.09|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.16|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.27|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.33|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.38|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.39|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.49|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.73|
|[[:results:exp274|Citral 50μM R06 exp274]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pds5b|PDS5B]]|0.482|
|[[:human genes:e:esco1|ESCO1]]|0.45|
|[[:human genes:c:cnot3|CNOT3]]|0.421|
|[[:human genes:h:hist1h2aj|HIST1H2AJ]]|0.421|
|[[:human genes:p:ppil1|PPIL1]]|0.408|
|[[:human genes:p:ppm1d|PPM1D]]|0.405|
|[[:human genes:d:ddx11|DDX11]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17586
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSME3 Expression in NALM6 Cells: 7.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>