======= PSMG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSMG4
  * **<color #00a2e8>Official Name</color>**: proteasome assembly chaperone 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389362|389362]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JS54|Q5JS54]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSMG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSMG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone protein which promotes assembly of the 20S proteasome.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome assembly|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-2.32|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.17|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.03|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.98|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.89|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.84|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.83|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.8|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.77|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.71|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin5|GEMIN5]]|0.498|
|[[:human genes:y:yars|YARS]]|0.469|
|[[:human genes:g:gmppb|GMPPB]]|0.467|
|[[:human genes:p:psmg2|PSMG2]]|0.431|
|[[:human genes:m:mars|MARS]]|0.427|
|[[:human genes:c:cct7|CCT7]]|0.426|
|[[:human genes:s:srp14|SRP14]]|0.414|
|[[:human genes:r:rnmt|RNMT]]|0.414|
|[[:human genes:r:rad1|RAD1]]|0.413|
|[[:human genes:u:uhrf1|UHRF1]]|0.407|
|[[:human genes:d:dolk|DOLK]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1241
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSMG4 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>