======= PSTPIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PSTPIP2
  * **<color #00a2e8>Official Name</color>**: proline-serine-threonine phosphatase interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9050|9050]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H939|Q9H939]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PSTPIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PSTPIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616046|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament polymerization|
|actin polymerization or depolymerization|
|cytoskeletal protein binding|
|actin filament|
|protein polymerization|
|actin filament binding|
|actin filament organization|
|cytoskeleton|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|actin filament-based process|
|cellular protein-containing complex assembly|
|cell migration|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|locomotion|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.12|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.99|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.95|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.91|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.87|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.87|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.79|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.76|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.682|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18812
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PSTPIP2 Expression in NALM6 Cells: 2.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>