======= PTGER2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGER2
  * **<color #00a2e8>Official Name</color>**: prostaglandin E receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5732|5732]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43116|P43116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGER2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGER2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176804|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of gastric mucosal blood circulation|
|regulation of gastric mucosal blood circulation|
|prostaglandin E receptor activity|
|cellular response to prostaglandin E stimulus|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|response to prostaglandin|
|response to progesterone|
|cellular response to fatty acid|
|positive regulation of blood circulation|
|response to fatty acid|
|cellular response to alcohol|
|cellular response to ketone|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|response to ketone|
|cellular response to acid chemical|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|response to steroid hormone|
|second-messenger-mediated signaling|
|response to acid chemical|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|cellular response to lipid|
|cellular metal ion homeostasis|
|regulation of system process|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|response to drug|
|cellular response to oxygen-containing compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15759
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGER2 Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>