======= PTGIS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTGIS
  * **<color #00a2e8>Official Name</color>**: prostaglandin I2 synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5740|5740]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16647|Q16647]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTGIS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTGIS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). {ECO:0000269|PubMed:18032380, ECO:0000269|PubMed:25623425}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|prostaglandin-I synthase activity|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|
|positive regulation of peroxisome proliferator activated receptor signaling pathway|
|cyclooxygenase pathway|
|negative regulation of nitric oxide biosynthetic process|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|NAD biosynthesis via nicotinamide riboside salvage pathway|
|negative regulation of nitric oxide metabolic process|
|positive regulation of execution phase of apoptosis|
|prostaglandin biosynthetic process|
|prostanoid biosynthetic process|
|decidualization|
|negative regulation of reactive oxygen species biosynthetic process|
|NAD biosynthetic process|
|monooxygenase activity|
|cellular response to interleukin-6|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide metabolic process|
|nicotinamide nucleotide metabolic process|
|prostaglandin metabolic process|
|prostanoid metabolic process|
|maternal placenta development|
|response to interleukin-6|
|pyridine-containing compound biosynthetic process|
|embryo implantation|
|regulation of execution phase of apoptosis|
|pyridine-containing compound metabolic process|
|unsaturated fatty acid biosynthetic process|
|icosanoid biosynthetic process|
|oxidoreduction coenzyme metabolic process|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|arachidonic acid metabolic process|
|maternal process involved in female pregnancy|
|caveola|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of reactive oxygen species biosynthetic process|
|fatty acid derivative biosynthetic process|
|unsaturated fatty acid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|iron ion binding|
|coenzyme biosynthetic process|
|negative regulation of inflammatory response|
|heme binding|
|placenta development|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of angiogenesis|
|fatty acid derivative metabolic process|
|cellular response to interleukin-1|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|positive regulation of vasculature development|
|monocarboxylic acid biosynthetic process|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|negative regulation of defense response|
|cofactor biosynthetic process|
|multi-multicellular organism process|
|cellular response to oxygen levels|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|regulation of vasculature development|
|fatty acid metabolic process|
|regulation of inflammatory response|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|response to oxygen levels|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|positive regulation of cell death|
|regulation of defense response|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|apoptotic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|organic acid metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of molecular function|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.88|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTGIS Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>