======= PTK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTK6
  * **<color #00a2e8>Official Name</color>**: protein tyrosine kinase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5753|5753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13882|Q13882]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602004|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage- independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|Pkinase Tyr|
|Pkinase|
|SH3 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tyrosine phosphorylation of STAT protein|
|intestinal epithelial cell differentiation|
|negative regulation of protein tyrosine kinase activity|
|positive regulation of epidermal growth factor receptor signaling pathway|
|ERBB2 signaling pathway|
|peptidyl-tyrosine autophosphorylation|
|positive regulation of ERBB signaling pathway|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|non-membrane spanning protein tyrosine kinase activity|
|negative regulation of peptidyl-tyrosine phosphorylation|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of tyrosine phosphorylation of STAT protein|
|cellular response to retinoic acid|
|ERBB signaling pathway|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of receptor signaling pathway via JAK-STAT|
|protein tyrosine kinase activity|
|positive regulation of receptor signaling pathway via STAT|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|ruffle|
|columnar/cuboidal epithelial cell differentiation|
|response to retinoic acid|
|regulation of receptor signaling pathway via JAK-STAT|
|digestive tract development|
|regulation of receptor signaling pathway via STAT|
|digestive system development|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|protein autophosphorylation|
|cellular response to acid chemical|
|negative regulation of protein kinase activity|
|negative regulation of growth|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of transferase activity|
|positive regulation of neuron projection development|
|nuclear body|
|signaling receptor binding|
|response to acid chemical|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|positive regulation of cell projection organization|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|positive regulation of nervous system development|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of neuron differentiation|
|regulation of growth|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2594
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTK6 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>