======= PTK7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PTK7
  * **<color #00a2e8>Official Name</color>**: protein tyrosine kinase 7 (inactive)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5754|5754]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13308|Q13308]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTK7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTK7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase|
|Pkinase Tyr|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|
|lung-associated mesenchyme development|
|planar cell polarity pathway involved in neural tube closure|
|convergent extension|
|regulation of establishment of planar polarity involved in neural tube closure|
|establishment of epithelial cell apical/basal polarity|
|regulation of epithelial tube formation|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|establishment of planar polarity|
|establishment of tissue polarity|
|cochlea morphogenesis|
|axis elongation|
|establishment of epithelial cell polarity|
|morphogenesis of a polarized epithelium|
|coronary vasculature development|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|cochlea development|
|actin cytoskeleton reorganization|
|cellular response to retinoic acid|
|ventricular septum development|
|neural tube closure|
|tube closure|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|neural tube formation|
|response to retinoic acid|
|cardiac septum development|
|regulation of establishment of planar polarity|
|developmental growth involved in morphogenesis|
|ear morphogenesis|
|establishment of cell polarity|
|embryonic epithelial tube formation|
|cardiac ventricle development|
|regulation of embryonic development|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|lung development|
|cardiac chamber development|
|cell-cell junction|
|respiratory tube development|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|cellular response to acid chemical|
|ear development|
|mesenchyme development|
|protein kinase activity|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|response to acid chemical|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of neurogenesis|
|wound healing|
|blood vessel development|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|positive regulation of cellular component organization|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12418
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTK7 Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>