======= PTPLAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HACD3
  * **<color #00a2e8>Official Name</color>**: 3-hydroxyacyl-CoA dehydratase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51495|51495]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P035|Q9P035]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PTPLAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PTPLAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615940|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506, ECO:0000269|PubMed:25687571}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
|PTPLA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by virus of viral protein levels in host cell|
|3-hydroxy-arachidoyl-CoA dehydratase activity|
|3-hydroxy-behenoyl-CoA dehydratase activity|
|3-hydroxy-lignoceroyl-CoA dehydratase activity|
|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|
|3-hydroxyacyl-CoA dehydratase activity|
|regulation by virus of viral protein levels in host cell|
|very long-chain fatty acid biosynthetic process|
|fatty acid elongation|
|Rac protein signal transduction|
|very long-chain fatty acid metabolic process|
|positive regulation of viral genome replication|
|activation of JUN kinase activity|
|positive regulation of viral life cycle|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of JUN kinase activity|
|Rho protein signal transduction|
|JNK cascade|
|regulation of JUN kinase activity|
|sphingolipid biosynthetic process|
|regulation of viral genome replication|
|stress-activated MAPK cascade|
|positive regulation of viral process|
|fatty acid biosynthetic process|
|membrane lipid biosynthetic process|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|regulation of viral life cycle|
|sphingolipid metabolic process|
|activation of MAPK activity|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|monocarboxylic acid biosynthetic process|
|regulation of JNK cascade|
|membrane lipid metabolic process|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear membrane|
|Ras protein signal transduction|
|positive regulation of MAP kinase activity|
|GTPase activator activity|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|small GTPase mediated signal transduction|
|fatty acid metabolic process|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of GTPase activity|
|focal adhesion|
|regulation of GTPase activity|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of transferase activity|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|oxoacid metabolic process|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.12|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.78|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15347
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PTPLAD1 Expression in NALM6 Cells: 7.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>